TY - JOUR
T1 - The lung as a possible target for the immune reaction in myositis
AU - Danoff, Sonye K.
AU - Casciola-Rosen, Livia
N1 - Funding Information:
The present work was supported by National Institutes of Health grant AR44684 (to LC-R) and by the Lisa Sandler Spaeth and Robert M. Fisher Funds for Pulmonary Fibrosis (to SKD). Images in Figure 1 were used with permission from Dr Christopher-Stine.
PY - 2011/7/13
Y1 - 2011/7/13
N2 - Interstitial lung disease is a common manifestation of autoimmune myositis that confers significant morbidity and mortality. The vulnerability of the lung may offer insight into the etiology of this autoimmune disease. The frequency and patterns of lung injury vary based on the autoantibody. Antibodies against the aminoacyl-tRNA synthetases and melanoma differentiation-induced gene-5 are frequently associated with interstitial lung disease. Although the mechanisms underlying these associations have not been fully elucidated, emerging data highlight the importance of autoantigen expression and conformation in the target tissue (lung and muscle, in this case), as well as identifying relevant amplifying pathways (such as regeneration).
AB - Interstitial lung disease is a common manifestation of autoimmune myositis that confers significant morbidity and mortality. The vulnerability of the lung may offer insight into the etiology of this autoimmune disease. The frequency and patterns of lung injury vary based on the autoantibody. Antibodies against the aminoacyl-tRNA synthetases and melanoma differentiation-induced gene-5 are frequently associated with interstitial lung disease. Although the mechanisms underlying these associations have not been fully elucidated, emerging data highlight the importance of autoantigen expression and conformation in the target tissue (lung and muscle, in this case), as well as identifying relevant amplifying pathways (such as regeneration).
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U2 - 10.1186/ar3347
DO - 10.1186/ar3347
M3 - Review article
C2 - 21787440
AN - SCOPUS:84856021921
SN - 1478-6354
VL - 13
JO - Arthritis Research and Therapy
JF - Arthritis Research and Therapy
IS - 4
M1 - 230
ER -