The loss of skeletal muscle strength, mass, and quality in older adults

The Health, Aging and Body Composition Study

Bret H. Goodpaster, Seok Won Park, Tamara B. Harris, Steven B. Kritchevsky, Michael Nevitt, Ann V. Schwartz, Eleanor Marie Simonsick, Frances A. Tylavsky, Marjolein Visser, Anne B. Newman

Research output: Contribution to journalArticle

Abstract

Background. The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking. Methods. Three-year changes in muscle mass and strength were determined in 1880 older adults in the Health, Aging and Body Composition Study. Knee extensor strength was measured by isokinetic dynamometry. Whole body and appendicular lean and fat mass were assessed by dual-energy x-ray absorptiometry and computed tomography. Results. Both men and women lost strength, with men losing almost twice as much strength as women. Blacks lost about 28% more strength than did whites. Annualized rates of leg strength decline (3.4% in white men, 4.1% in black men, 2.6% in white women, and 3.0% in black women) were about three times greater than the rates of loss of leg lean mass (∼1% per year). The loss of lean mass, as well as higher baseline strength, lower baseline leg lean mass, and older age, was independently associated with strength decline in both men and women. However, gain of lean mass was not accompanied by strength maintenance or gain (β coefficients; men, -0.48 ± 4.61, p = .92, women, -1.68 ± 3.57, p = .64). Conclusions. Although the loss of muscle mass is associated with the decline in strength in older adults, this strength decline is much more rapid than the concomitant loss of muscle mass, suggesting a decline in muscle quality. Moreover, maintaining or gaining muscle mass does not prevent aging-associated declines in muscle strength.

Original languageEnglish (US)
Pages (from-to)1059-1064
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume61
Issue number10
StatePublished - Oct 2006
Externally publishedYes

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Muscle Strength
Body Composition
Skeletal Muscle
Health
Muscles
Leg
Longitudinal Studies
Knee
Fats
Tomography
Maintenance
X-Rays

ASJC Scopus subject areas

  • Aging

Cite this

Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., ... Newman, A. B. (2006). The loss of skeletal muscle strength, mass, and quality in older adults: The Health, Aging and Body Composition Study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 61(10), 1059-1064.

The loss of skeletal muscle strength, mass, and quality in older adults : The Health, Aging and Body Composition Study. / Goodpaster, Bret H.; Park, Seok Won; Harris, Tamara B.; Kritchevsky, Steven B.; Nevitt, Michael; Schwartz, Ann V.; Simonsick, Eleanor Marie; Tylavsky, Frances A.; Visser, Marjolein; Newman, Anne B.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 61, No. 10, 10.2006, p. 1059-1064.

Research output: Contribution to journalArticle

Goodpaster, BH, Park, SW, Harris, TB, Kritchevsky, SB, Nevitt, M, Schwartz, AV, Simonsick, EM, Tylavsky, FA, Visser, M & Newman, AB 2006, 'The loss of skeletal muscle strength, mass, and quality in older adults: The Health, Aging and Body Composition Study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 61, no. 10, pp. 1059-1064.
Goodpaster, Bret H. ; Park, Seok Won ; Harris, Tamara B. ; Kritchevsky, Steven B. ; Nevitt, Michael ; Schwartz, Ann V. ; Simonsick, Eleanor Marie ; Tylavsky, Frances A. ; Visser, Marjolein ; Newman, Anne B. / The loss of skeletal muscle strength, mass, and quality in older adults : The Health, Aging and Body Composition Study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2006 ; Vol. 61, No. 10. pp. 1059-1064.
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AU - Goodpaster, Bret H.

AU - Park, Seok Won

AU - Harris, Tamara B.

AU - Kritchevsky, Steven B.

AU - Nevitt, Michael

AU - Schwartz, Ann V.

AU - Simonsick, Eleanor Marie

AU - Tylavsky, Frances A.

AU - Visser, Marjolein

AU - Newman, Anne B.

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N2 - Background. The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking. Methods. Three-year changes in muscle mass and strength were determined in 1880 older adults in the Health, Aging and Body Composition Study. Knee extensor strength was measured by isokinetic dynamometry. Whole body and appendicular lean and fat mass were assessed by dual-energy x-ray absorptiometry and computed tomography. Results. Both men and women lost strength, with men losing almost twice as much strength as women. Blacks lost about 28% more strength than did whites. Annualized rates of leg strength decline (3.4% in white men, 4.1% in black men, 2.6% in white women, and 3.0% in black women) were about three times greater than the rates of loss of leg lean mass (∼1% per year). The loss of lean mass, as well as higher baseline strength, lower baseline leg lean mass, and older age, was independently associated with strength decline in both men and women. However, gain of lean mass was not accompanied by strength maintenance or gain (β coefficients; men, -0.48 ± 4.61, p = .92, women, -1.68 ± 3.57, p = .64). Conclusions. Although the loss of muscle mass is associated with the decline in strength in older adults, this strength decline is much more rapid than the concomitant loss of muscle mass, suggesting a decline in muscle quality. Moreover, maintaining or gaining muscle mass does not prevent aging-associated declines in muscle strength.

AB - Background. The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking. Methods. Three-year changes in muscle mass and strength were determined in 1880 older adults in the Health, Aging and Body Composition Study. Knee extensor strength was measured by isokinetic dynamometry. Whole body and appendicular lean and fat mass were assessed by dual-energy x-ray absorptiometry and computed tomography. Results. Both men and women lost strength, with men losing almost twice as much strength as women. Blacks lost about 28% more strength than did whites. Annualized rates of leg strength decline (3.4% in white men, 4.1% in black men, 2.6% in white women, and 3.0% in black women) were about three times greater than the rates of loss of leg lean mass (∼1% per year). The loss of lean mass, as well as higher baseline strength, lower baseline leg lean mass, and older age, was independently associated with strength decline in both men and women. However, gain of lean mass was not accompanied by strength maintenance or gain (β coefficients; men, -0.48 ± 4.61, p = .92, women, -1.68 ± 3.57, p = .64). Conclusions. Although the loss of muscle mass is associated with the decline in strength in older adults, this strength decline is much more rapid than the concomitant loss of muscle mass, suggesting a decline in muscle quality. Moreover, maintaining or gaining muscle mass does not prevent aging-associated declines in muscle strength.

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