The Loss of Retinoblastoma Gene in Association with c-myc and Transforming Growth Factor-beta 1 Gene Expression in Human Bladder Cancer

Yoshinobu Kubota, Hiroshi Miyamoto, Sumio Noguchi, Taro Shuin, Hitoshi Kitamura, Hong Ji Xu, Shi Xue Hu, William F. Benedict

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: We investigate the roles and possible interactions of the retinoblastoma, transforming growth factor-beta 1 and c-myc genes in bladder cancer. Materials and Methods: The expression of these 3 genes was examined in 38 biopsy specimens of human bladder cancer by immunohistochemical analysis or Northern blotting. Results: Loss of the retinoblastoma protein expression was most significantly correlated with high grade cancer. Over expression of c-myc or expression of transforming growth factor-beta 1 was less associated with tumor grade or stage, although c-myc over expression defined stage Ta against other stage tumors, since no stage Ta lesions had increased c-myc expression. Finally, loss of retinoblastoma gene function did not correlate with either c-myc or transforming growth factor-beta 1 expression. Conclusions: These results further support that retinoblastoma gene inactivation is an important factor in the progression of bladder cancer, and suggest that transforming growth factor-beta 1 and c-myc are not regulators or are not regulated by retinoblastoma gene expression.

Original languageEnglish (US)
Pages (from-to)371-374
Number of pages4
JournalThe Journal of urology
Volume154
Issue number2
DOIs
StatePublished - Aug 1995

ASJC Scopus subject areas

  • Urology

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