The long-term outcomes and costs of diabetes mellitus among renal transplant recipients: Tacrolimus versus cyclosporine

Robert S. Woodward, Marc C. Flore, Gerardo Machnicki, Daniel C. Brennan

Research output: Contribution to journalArticlepeer-review

Abstract

Anti-rejection regimens for renal transplants have changed dramatically during the past 20 years, but there are few long-term studies relating cost, mortality, or graft failure simultaneously to disease-pharmacotherapy couplets. We analyzed US Renal Data System data on a matched-pair cohort of first, single organ kidney transplants from 1998 through 2002 over up to 5 years following transplantation for patients on tacrolimus or low-dose cyclosporine, stratifying by whether the recipient had pre-existing or new onset diabetes. Kaplan-Meier survival curves show mortality and survival differences associated with diabetes, but no additional incremental effects of immune suppression regimen. Significant cost increases are reported for patients receiving tacrolimus above and beyond the extra costs associated with diabetes.

Original languageEnglish (US)
Pages (from-to)443-449
Number of pages7
JournalValue in Health
Volume14
Issue number4
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • Diabetes
  • Long-term costs
  • Long-term effects
  • Pharmacoeconomics
  • Renal transplantation

ASJC Scopus subject areas

  • Health Policy
  • Public Health, Environmental and Occupational Health

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