The long-lasting effects of cross-fostering on the emotional behavior in ICR mice

Lingling Lu, Takayoshi Mamiya, Ping Lu, Minae Niwa, Akihiro Mouri, Li Bo Zou, Taku Nagai, Masayuki Hiramatsu, Toshitaka Nabeshima

Research output: Contribution to journalArticle

Abstract

Early-life stress during the postnatal period could precipitate long-lasting alterations in the functional properties underlying emotional expression in humans, but how the psychological stress of cross-fostering affects emotional behavior during adulthood in mice remains primarily unknown. The purpose of the present study was to examine the long-term effects of cross-fostering on the emotional behavior and cognitive functions of ICR offspring in adulthood. Cross-fostering was performed from postnatal day 7 for 3 weeks. Mice were divided into three groups: (1) biological group: pups born from ICR dams fostered by their original mothers; (2) in-foster group: pups born from ICR dams but adopted by other ICR dams and (3) cross-foster group: ICR pups adopted by C57 dams. ICR mice were subjected to behavioral experiments at the age of 8 weeks. Emotional behaviors in the cross-fostered mice were significantly altered in the open-field, elevated plus maze and forced swimming tests, as well as social interaction tests. However, the cross-fostered mice showed normal memory function in the Y-maze and novel object recognition tests. The contents of serotonin metabolisms were decreased in the prefrontal cortex and hippocampus indicated the deficit of serotoninergic neuronal function by cross-fostering. These findings suggested that the early-life stress of cross-fostering induced long-lasting emotional abnormalities, which might be possibly related to alterations of serotonin metabolisms.

Original languageEnglish (US)
Pages (from-to)172-178
Number of pages7
JournalBehavioural Brain Research
Volume198
Issue number1
DOIs
StatePublished - Mar 2 2009

Keywords

  • Cognitive function
  • Cross-fostering
  • Early-life stress
  • Emotional behavior
  • Mice
  • Serotonin

ASJC Scopus subject areas

  • Behavioral Neuroscience

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  • Cite this

    Lu, L., Mamiya, T., Lu, P., Niwa, M., Mouri, A., Zou, L. B., Nagai, T., Hiramatsu, M., & Nabeshima, T. (2009). The long-lasting effects of cross-fostering on the emotional behavior in ICR mice. Behavioural Brain Research, 198(1), 172-178. https://doi.org/10.1016/j.bbr.2008.10.031