The logic of adjunctive therapy in surgical patients with resectable cancer

Charles M. Balch, William A. Maddox

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The principles and rationale of using multiple modalities (surgery, chemotherapy, radiotherapy, and immunotherapy) to treat solid malignancies is reviewed. Animal models of human tumors have clearly demonstrated the superiority of combining local treatment (eg, surgery) with systemic treatment (eg, chemotherapy). Although the results of many trials of adjunctive therapy in man are still preliminary, they warrant the cautious generalization that multiple modality therapy will increasingly become more effective than surgery alone for most types of solid tumors. Although the strategy of employing adjunctive therapy is rational, it must be emphasized that the therapeutic efficacy of specific drugs or agents for particular patients or tumor types has not always been satisfactory. Clinical trials now in progress may demonstrate more effective regimens. In the meantime, physicians should be cautious about using adjunctive therapy as standard treatment until long-term benefits and safety have been demonstrated. Participation in clinical trials is encouraged to verify the validity and application of this therapeutic approach.

Original languageEnglish (US)
Pages (from-to)951-955+957
JournalSouthern medical journal
Issue number8
StatePublished - Aug 1978
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'The logic of adjunctive therapy in surgical patients with resectable cancer'. Together they form a unique fingerprint.

Cite this