The living-tissue microscope: The importance of studying stem cells in their natural, undisturbed microenvironment

Allan C. Spradling

Research output: Contribution to journalArticlepeer-review

Abstract

Advances in stem cell research highlight the importance of analysing multicellular interactions in vivo before modelling them in cell culture systems. Gain-of-function assays such as transplantation are useful, but are not equivalent to studying cells in their natural, undisturbed microenvironment.

Original languageEnglish (US)
Pages (from-to)161-162
Number of pages2
JournalJournal of Pathology
Volume225
Issue number2
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • clonal unit
  • in situ assay
  • lineage analysis
  • live cell imaging
  • microenvrionment
  • stem cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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