The likelihood of developing a carbapenem-resistant Enterobacteriaceae infection during a hospital stay

Pranita D. Tamma; Abida Kazmi; Yehudit Bergman; Katherine E. Goodman; Ernest Ekunseitan; Joe Amoah; Patricia J. Simner

doi:10.1128/AAC.00757-19

The likelihood of developing a carbapenem-resistant Enterobacteriaceae infection during a hospital stay

Pranita D. Tamma, Abida Kazmi, Yehudit Bergman, Katherine E. Goodman, Ernest Ekunseitan, Joe Amoah, Patricia J. Simner

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Of 1,455 unique patients in U.S. intensive care units (ICUs), 4% were rectally colonized with CRE on admission. A total of 297 patients were initially negative for carbapenem-resistant Enterobacteriaceae (CRE) and remained in the ICU long enough to contribute additional swabs; 22% of these patients had a subsequent CRE-positive swab, with a median time to CRE colonization of 13 days (interquartile range, 7 to 21 days). Patients colonized with carbapenemase-producing CRE were more likely than those colonized with non-carbapenemase-producing CRE to develop CRE infections during their hospitalizations (36% versus 3%; P 0.05).

Original language	English (US)
Article number	e00757-19
Journal	Antimicrobial agents and chemotherapy
Volume	63
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00757-19
State	Published - 2019

Keywords

CRE
Carbapenem resistance
ICU
Multidrug-resistant organisms

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.00757-19

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title = "The likelihood of developing a carbapenem-resistant Enterobacteriaceae infection during a hospital stay",

abstract = "Of 1,455 unique patients in U.S. intensive care units (ICUs), 4% were rectally colonized with CRE on admission. A total of 297 patients were initially negative for carbapenem-resistant Enterobacteriaceae (CRE) and remained in the ICU long enough to contribute additional swabs; 22% of these patients had a subsequent CRE-positive swab, with a median time to CRE colonization of 13 days (interquartile range, 7 to 21 days). Patients colonized with carbapenemase-producing CRE were more likely than those colonized with non-carbapenemase-producing CRE to develop CRE infections during their hospitalizations (36% versus 3%; P 0.05).",

keywords = "CRE, Carbapenem resistance, ICU, Multidrug-resistant organisms",

author = "Tamma, {Pranita D.} and Abida Kazmi and Yehudit Bergman and Goodman, {Katherine E.} and Ernest Ekunseitan and Joe Amoah and Simner, {Patricia J.}",

note = "Funding Information: This work was supported by funding from the National Institutes of Health (K23-AI127935 to P.D.T. and R21-AI130608 to P.J.S.). We thank Shawna Lewis and Stefanie Fisher for their assistance with the microbiological evaluation of rectal swabs. We have no conflicts of interest to report. Publisher Copyright: Copyright {\textcopyright} 2019 American Society for Microbiology. All Rights Reserved.",

year = "2019",

doi = "10.1128/AAC.00757-19",

language = "English (US)",

volume = "63",

journal = "Antimicrobial agents and chemotherapy",

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AU - Tamma, Pranita D.

AU - Kazmi, Abida

AU - Bergman, Yehudit

AU - Goodman, Katherine E.

AU - Ekunseitan, Ernest

AU - Amoah, Joe

AU - Simner, Patricia J.

N1 - Funding Information: This work was supported by funding from the National Institutes of Health (K23-AI127935 to P.D.T. and R21-AI130608 to P.J.S.). We thank Shawna Lewis and Stefanie Fisher for their assistance with the microbiological evaluation of rectal swabs. We have no conflicts of interest to report. Publisher Copyright: Copyright © 2019 American Society for Microbiology. All Rights Reserved.

PY - 2019

Y1 - 2019

N2 - Of 1,455 unique patients in U.S. intensive care units (ICUs), 4% were rectally colonized with CRE on admission. A total of 297 patients were initially negative for carbapenem-resistant Enterobacteriaceae (CRE) and remained in the ICU long enough to contribute additional swabs; 22% of these patients had a subsequent CRE-positive swab, with a median time to CRE colonization of 13 days (interquartile range, 7 to 21 days). Patients colonized with carbapenemase-producing CRE were more likely than those colonized with non-carbapenemase-producing CRE to develop CRE infections during their hospitalizations (36% versus 3%; P 0.05).

AB - Of 1,455 unique patients in U.S. intensive care units (ICUs), 4% were rectally colonized with CRE on admission. A total of 297 patients were initially negative for carbapenem-resistant Enterobacteriaceae (CRE) and remained in the ICU long enough to contribute additional swabs; 22% of these patients had a subsequent CRE-positive swab, with a median time to CRE colonization of 13 days (interquartile range, 7 to 21 days). Patients colonized with carbapenemase-producing CRE were more likely than those colonized with non-carbapenemase-producing CRE to develop CRE infections during their hospitalizations (36% versus 3%; P 0.05).

KW - CRE

KW - Carbapenem resistance

KW - ICU

KW - Multidrug-resistant organisms

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The likelihood of developing a carbapenem-resistant Enterobacteriaceae infection during a hospital stay

Abstract

Keywords

ASJC Scopus subject areas

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