The Leydig Cell as a Target for Toxicants

Bing bing Chen, Barry R Zirkin, Ren Shan Ge

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Leydig cells are the testicular cells responsible for the biosynthesis and secretion of androgens, which are critical for the development of the reproductive tract and for reproductive function in the male. There are two distinct populations of Leydig cells: fetal Leydig cells (FLCs), which originate and function in the fetus but largely regress soon after birth, and adult Leydig cells (ALCs). FLCs produce high levels of testosterone (T) required for the stimulation of male sexual differentiation and testis descent. ALCs form from precursor cells during postnatal life. The adult cells produce high levels of T required for maintaining spermatogenesis and male secondary sexual characteristics in adult life. A number of environmental toxicants have been shown to disrupt FLC function, ALC development, and/or ALC function. Based on when in the life cycle cells are exposed, exposures to toxicants have been shown to have a variety of pathological consequences, including hypospadia and cryptorchidism, resulting from exposures of FLCs; delayed puberty, resulting from Leydig cell precursor cell postnatal exposures; or hypogonadism and infertility, resulting from ALC exposures.

Original languageEnglish (US)
Title of host publicationReproductive and Endocrine Toxicology
PublisherElsevier Inc.
Pages131-148
Number of pages18
Volume11
ISBN (Print)9780080468686
DOIs
StatePublished - Aug 12 2010
Externally publishedYes

Keywords

  • Herbicide
  • Metals
  • Pesticides
  • Plasticizers
  • Testosterone

ASJC Scopus subject areas

  • Medicine(all)

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