The latency-associated nuclear antigen of Kaposi sarcoma - Associated herpesvirus induces B cell hyperplasia and lymphoma

Farnaz D. Fakhari, Joseph H. Jeong, Yogita Kanan, Dirk P. Dittmer

Research output: Contribution to journalArticle

Abstract

Kaposi sarcoma - associated herpesvirus (KSHV) is a human lymphotropic herpesvirus. It is implicated in B cell neoplasias such as primary effusion lymphoma and multicentric Castleman disease in AIDS patients. The KSHV latency-associated nuclear antigen (LANA) is consistently expressed in all KSHV-associated tumor cells and was shown to bind the tumor suppressor proteins p53 and pRb. To test LANA's contribution to lymphomagenesis in vivo we generated transgenic mice expressing LANA under the control of its own promoter, which is B cell specific. All of the transgenic mice developed splenic follicular hyperplasia due to an expansion of IgM+IgD+ B cells and showed increased germinal center formation. We also observed lymphomas, implying that LANA can activate B cells and provide the first step toward lymphomagenesis.

Original languageEnglish (US)
Pages (from-to)735-742
Number of pages8
JournalJournal of Clinical Investigation
Volume116
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Fingerprint

Cercopithecine Herpesvirus 1
Human Herpesvirus 8
B-Cell Lymphoma
Hyperplasia
B-Lymphocytes
Transgenic Mice
Primary Effusion Lymphoma
Tumor Suppressor Protein p53
Immunoglobulin D
Germinal Center
Herpesviridae
Immunoglobulin M
Lymphoma
Neoplasms
Acquired Immunodeficiency Syndrome
latency-associated nuclear antigen

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The latency-associated nuclear antigen of Kaposi sarcoma - Associated herpesvirus induces B cell hyperplasia and lymphoma. / Fakhari, Farnaz D.; Jeong, Joseph H.; Kanan, Yogita; Dittmer, Dirk P.

In: Journal of Clinical Investigation, Vol. 116, No. 3, 01.03.2006, p. 735-742.

Research output: Contribution to journalArticle

@article{70d6c0e672124a8daeb40f83d38bd61b,
title = "The latency-associated nuclear antigen of Kaposi sarcoma - Associated herpesvirus induces B cell hyperplasia and lymphoma",
abstract = "Kaposi sarcoma - associated herpesvirus (KSHV) is a human lymphotropic herpesvirus. It is implicated in B cell neoplasias such as primary effusion lymphoma and multicentric Castleman disease in AIDS patients. The KSHV latency-associated nuclear antigen (LANA) is consistently expressed in all KSHV-associated tumor cells and was shown to bind the tumor suppressor proteins p53 and pRb. To test LANA's contribution to lymphomagenesis in vivo we generated transgenic mice expressing LANA under the control of its own promoter, which is B cell specific. All of the transgenic mice developed splenic follicular hyperplasia due to an expansion of IgM+IgD+ B cells and showed increased germinal center formation. We also observed lymphomas, implying that LANA can activate B cells and provide the first step toward lymphomagenesis.",
author = "Fakhari, {Farnaz D.} and Jeong, {Joseph H.} and Yogita Kanan and Dittmer, {Dirk P.}",
year = "2006",
month = "3",
day = "1",
doi = "10.1172/JCI26190",
language = "English (US)",
volume = "116",
pages = "735--742",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "3",

}

TY - JOUR

T1 - The latency-associated nuclear antigen of Kaposi sarcoma - Associated herpesvirus induces B cell hyperplasia and lymphoma

AU - Fakhari, Farnaz D.

AU - Jeong, Joseph H.

AU - Kanan, Yogita

AU - Dittmer, Dirk P.

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Kaposi sarcoma - associated herpesvirus (KSHV) is a human lymphotropic herpesvirus. It is implicated in B cell neoplasias such as primary effusion lymphoma and multicentric Castleman disease in AIDS patients. The KSHV latency-associated nuclear antigen (LANA) is consistently expressed in all KSHV-associated tumor cells and was shown to bind the tumor suppressor proteins p53 and pRb. To test LANA's contribution to lymphomagenesis in vivo we generated transgenic mice expressing LANA under the control of its own promoter, which is B cell specific. All of the transgenic mice developed splenic follicular hyperplasia due to an expansion of IgM+IgD+ B cells and showed increased germinal center formation. We also observed lymphomas, implying that LANA can activate B cells and provide the first step toward lymphomagenesis.

AB - Kaposi sarcoma - associated herpesvirus (KSHV) is a human lymphotropic herpesvirus. It is implicated in B cell neoplasias such as primary effusion lymphoma and multicentric Castleman disease in AIDS patients. The KSHV latency-associated nuclear antigen (LANA) is consistently expressed in all KSHV-associated tumor cells and was shown to bind the tumor suppressor proteins p53 and pRb. To test LANA's contribution to lymphomagenesis in vivo we generated transgenic mice expressing LANA under the control of its own promoter, which is B cell specific. All of the transgenic mice developed splenic follicular hyperplasia due to an expansion of IgM+IgD+ B cells and showed increased germinal center formation. We also observed lymphomas, implying that LANA can activate B cells and provide the first step toward lymphomagenesis.

UR - http://www.scopus.com/inward/record.url?scp=33644651607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644651607&partnerID=8YFLogxK

U2 - 10.1172/JCI26190

DO - 10.1172/JCI26190

M3 - Article

C2 - 16498502

AN - SCOPUS:33644651607

VL - 116

SP - 735

EP - 742

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 3

ER -