The landscape of kinase fusions in cancer

Nicolas Stransky; Ethan Cerami; Stefanie Schalm; Joseph L. Kim; Christoph Lengauer

doi:10.1038/ncomms5846

The landscape of kinase fusions in cancer

Nicolas Stransky, Ethan Cerami, Stefanie Schalm, Joseph L. Kim, Christoph Lengauer

Research output: Contribution to journal › Article › peer-review

466 Scopus citations

Abstract

Human cancer genomes harbour a variety of alterations leading to the deregulation of key pathways in tumour cells. The genomic characterization of tumours has uncovered numerous genes recurrently mutated, deleted or amplified, but gene fusions have not been characterized as extensively. Here we develop heuristics for reliably detecting gene fusion events in RNA-seq data and apply them to nearly 7,000 samples from The Cancer Genome Atlas. We thereby are able to discover several novel and recurrent fusions involving kinases. These findings have immediate clinical implications and expand the therapeutic options for cancer patients, as approved or exploratory drugs exist for many of these kinases.

Original language	English (US)
Article number	4846
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms5846
State	Published - Sep 10 2014
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Chemistry
General Physics and Astronomy
General Medicine

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10.1038/ncomms5846

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The landscape of kinase fusions in cancer

Abstract

ASJC Scopus subject areas

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