The lack of an effect of furosemide on uterine prostaglandin metabolism in vivo

John G. Gerber, Walter C. Hubbard, Robert A. Branch, Alan S. Nies

Research output: Contribution to journalArticlepeer-review

Abstract

We determined the effect of 2 mg/kg intravenous furosemide on the production and metabolism of prostaglandin E2 in the utero-placental unit of pregnant dogs. Uterine venous prostaglandins E2 and 15-keto-13,14-dihydro E2 were measured by gas chromatography-mass spectrometry. Even though the dose of furosemide was adequate to effect a good diuresis, neither the production nor the metabolism of prostaglandin E2 by the uterus was altered by that dose of the drug. Using radioactive microspheres to measure hemodynamic parameters, we observed no change in uterine vascular resistance while renal vascular resistance decreased. Although the renal concentration of furosemide may be higher than the uteroplacental concentration, there is so far no evidence in vivo that usual doses of furosemide enhance the production or inhibit the metabolism of prostaglandin E2.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalProstaglandins
Volume15
Issue number4
DOIs
StatePublished - Apr 1978

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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