The known unknowns of HPV natural history

Patti E. Gravitt

Research output: Contribution to journalArticle

Abstract

The discovery that certain high-risk strains of human papillomavirus (HR-HPV) cause nearly 100% of invasive cervical cancer has spurred a revolution in cervical cancer prevention by promoting the development of viral vaccines. Although the efficacy of these vaccines has already been demonstrated, a complete understanding of viral latency and natural immunity is lacking, and solving these mysteries could help guide policies of cervical cancer screening and vaccine use. Here, we examine the epidemiological and biological understanding of the natural history of HPV infection, with an eye toward using these studies to guide the implementation of cervical cancer prevention strategies.

Original languageEnglish (US)
Pages (from-to)4593-4599
Number of pages7
JournalJournal of Clinical Investigation
Volume121
Issue number12
DOIs
StatePublished - Dec 1 2011

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Natural History
Uterine Cervical Neoplasms
Viral Vaccines
Virus Latency
Cancer Vaccines
Early Detection of Cancer
Innate Immunity
Vaccines
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The known unknowns of HPV natural history. / Gravitt, Patti E.

In: Journal of Clinical Investigation, Vol. 121, No. 12, 01.12.2011, p. 4593-4599.

Research output: Contribution to journalArticle

Gravitt, Patti E. / The known unknowns of HPV natural history. In: Journal of Clinical Investigation. 2011 ; Vol. 121, No. 12. pp. 4593-4599.
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