The kinetics of interferon induction by poly ICLC in humans

C. T. Bever, H. F. McFarland, D. E. McFarlin, H. B. Levy

Research output: Contribution to journalArticle

Abstract

A preliminary trial of the interferon (IFN) inducer polyriboinosinic acid-polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) was conducted in patients with chronic progressive multiple sclerosis (MS). Because IFN induction in men greater than in women, the kinetics of IFN induction were studied. As no significant differences were found in the serum half-life of IFN, sex-linked differences in IFN clearance or degradation are not likely to be responsible for the differences noted. Because fever was the major limiting side effect in MS patients, the relationship of fever to IFN levels was assessed. Changes in temperature were not related to changes in IFN levels, suggesting that fever might be blocked without reducing IFN levels.

Original languageEnglish (US)
Pages (from-to)419-425
Number of pages7
JournalJournal of Interferon Research
Volume8
Issue number4
StatePublished - 1988
Externally publishedYes

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Carboxymethylcellulose Sodium
Interferons
Lysine
Fever
Interferon Inducers
Chronic Progressive Multiple Sclerosis
Sex Characteristics
Multiple Sclerosis
Half-Life
Temperature
Acids
Serum

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Bever, C. T., McFarland, H. F., McFarlin, D. E., & Levy, H. B. (1988). The kinetics of interferon induction by poly ICLC in humans. Journal of Interferon Research, 8(4), 419-425.

The kinetics of interferon induction by poly ICLC in humans. / Bever, C. T.; McFarland, H. F.; McFarlin, D. E.; Levy, H. B.

In: Journal of Interferon Research, Vol. 8, No. 4, 1988, p. 419-425.

Research output: Contribution to journalArticle

Bever, CT, McFarland, HF, McFarlin, DE & Levy, HB 1988, 'The kinetics of interferon induction by poly ICLC in humans', Journal of Interferon Research, vol. 8, no. 4, pp. 419-425.
Bever CT, McFarland HF, McFarlin DE, Levy HB. The kinetics of interferon induction by poly ICLC in humans. Journal of Interferon Research. 1988;8(4):419-425.
Bever, C. T. ; McFarland, H. F. ; McFarlin, D. E. ; Levy, H. B. / The kinetics of interferon induction by poly ICLC in humans. In: Journal of Interferon Research. 1988 ; Vol. 8, No. 4. pp. 419-425.
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