The ketogenic diet does not affect growth of Hedgehog pathway medulloblastoma in mice

Mai T. Dang, Suzanne Wehrli, Chi V. Dang, Tom Curran

Research output: Contribution to journalArticle

Abstract

The altered metabolism of cancer cells has long been viewed as a potential target for therapeutic intervention. In particular, brain tumors often display heightened glycolysis, even in the presence of oxygen. A subset of medulloblastoma, the most prevalent malignant brain tumor in children, arises as a consequence of activating mutations in the Hedgehog (HH) pathway, which has been shown to promote aerobic glycolysis. Therefore, we hypothesized that a low carbohydrate, high fat ketogenic diet would suppress tumor growth in a genetically engineered mouse model of medulloblastoma. However, we found that the ketogenic diet did not slow the growth of spontaneous tumors or allograft flank tumors, and it did not exhibit synergy with a small molecule inhibitor of Smoothened. Serum insulin was significantly reduced in mice fed the ketogenic diet, but no alteration in PI3 kinase activity was observed. These findings indicate that while the ketogenic diet may be effective in inhibiting growth of other tumor types, it does not slow the growth of HH-medulloblastoma in mice.

Original languageEnglish (US)
Article numbere0133633
JournalPLoS One
Volume10
Issue number7
DOIs
StatePublished - Jul 20 2015
Externally publishedYes

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Ketogenic Diet
Medulloblastoma
Hedgehogs
Erinaceidae
Nutrition
Tumors
neoplasms
mice
Growth
Glycolysis
Neoplasms
Brain Neoplasms
glycolysis
Brain
brain
High Fat Diet
allografting
Phosphatidylinositol 3-Kinases
Allografts
high fat diet

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

The ketogenic diet does not affect growth of Hedgehog pathway medulloblastoma in mice. / Dang, Mai T.; Wehrli, Suzanne; Dang, Chi V.; Curran, Tom.

In: PLoS One, Vol. 10, No. 7, e0133633, 20.07.2015.

Research output: Contribution to journalArticle

Dang, Mai T. ; Wehrli, Suzanne ; Dang, Chi V. ; Curran, Tom. / The ketogenic diet does not affect growth of Hedgehog pathway medulloblastoma in mice. In: PLoS One. 2015 ; Vol. 10, No. 7.
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