@article{2a9ff89230764e9ba0767b3ea8f87d70,
title = "The Joint Association of Small for Gestational Age and Nighttime Sleep with Blood Pressure in Childhood",
abstract = "Children born small for gestational age (SGA) are more likely to develop high blood pressure. In prior studies, longer sleep duration is associated with lower BP, and SGA is associated with shorter sleep duration in childhood. We investigated whether sleep duration in early childhood modifies the association between SGA and higher childhood SBP in 1178 children recruited at birth and followed up to age 9 years. We ascertained birthweight and gestational age from medical records. We derived child sleep duration from maternal questionnaire interview. We calculated child SBP percentile according to U.S. reference data. We defined elevated SBP as SBP ≥75th percentile. In this sample, 154 (13.1%) children were born SGA. Children born SGA had higher SBP percentiles and higher risk of elevated SBP. Among children born SGA, those in the highest compared to the lowest tertile for sleep had a 12.28 lower (−22.00, −2.57) SBP percentile and 0.44 (0.25 to 0.79) times lower risk of developing elevated SBP. Our data are consistent with an interaction between SGA and sleep duration on childhood elevated SBP (Pinteraction = 0.0056). In conclusion, in this prospective birth cohort, longer sleep duration in early childhood may mitigate the blood pressure-raising effect of being born small.",
author = "Hongjian Wang and Noel Mueller and Guoying Wang and Xiumei Hong and Ting Chen and Yuelong Ji and Colleen Pearson and Appel, {Lawrence J.} and Xiaobin Wang",
note = "Funding Information: We wish to thank all of the study participants, the Boston Medical Center Labor and Delivery Nursing Staff, and the Boston Birth Cohort field team for their support and help with the study. The Boston Birth Cohort (the parent study) was supported in part by March of Dimes PERI grants (20-FY02-56, #21-FY07-605); grants from the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) (R40MC27443 and UJ2MC31074); and the National Institutes of Health (NIH) grants (R21ES011666, R01HD041702, R21HD066471, U01AI090727, R21AI079872, and R01HD086013). Dr. Hongjian Wang is supported by Chinese Scholarships Council scholarship, grants from the National Natural Science Foundation of China (81300156) and PUMC Youth Fund/the Fundamental Research Funds for the Central Universities (3332015103). Research reported in this publication was also supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number K01HL141589 (PI: Mueller). The content is solely the responsibility of the authors and does not necessarily represent the official views of the above listed funding agencies. Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-27815-1",
language = "English (US)",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}