The involvement of class Ib molecules in the host response to infection with Salmonella and its relevance to autoimmunity

Mark J. Soloski, Eleanor S. Metcalf

Research output: Contribution to journalReview article

Abstract

Class I molecules with limited polymorphism have been implicated in the host response to infectious agents. Following infection with Salmonella typhimurium, mice develop a CD8+ CTL response that specifically recognizes bacteria infected cells. An immunodominant component of the CTL response recognizes a peptide epitope derived from the Salmonella GroEL molecule that is presented by the non-polymorphic MHC class Ib molecule Qa-1. T cells recognizing the bacterial peptide also cross-recognize a homologous peptide from the mammalian hsp60 molecule. Since Qa-1 has a functional equivalent in humans, this observation may be relevant not only to the host response involved in clearing infection but also in understanding the link between infection with Gram-negative pathogens and autoimmune disease.

Original languageEnglish (US)
Pages (from-to)1249-1259
Number of pages11
JournalMicrobes and Infection
Volume3
Issue number14-15
DOIs
StatePublished - Jan 1 2001

Keywords

  • Antigen presentation
  • Autoimmunity
  • Gram-negative bacteria
  • MHC class Ib molecule

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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