The intratumoral heterogeneity of cancer metabolism

Karim Nabi, Quy Hoa Le Thi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Heterogeneity is a hallmark of cancer.Clonal evolution theory and cancer stem cell theory explain tumor subpopulation growth.Intratumoral metabolism heterogeneity follows intratumoral genetics alterations.Epigenetics alterations lead to intratumoral metabolism heterogeneity.Intratumoral metabolic adaptation and heterogeneity are due to the intemperate conditions of the tumor microenvironment.Spatial and temporal heterogeneity provides survival advantages to tumors.Metabolic profile-targeted therapeutics can result in successful clinical outcomes.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages131-145
Number of pages15
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1063
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Angiogenesis
  • Genetic and metabolic adaptation
  • Hypoxia
  • Intratumoral heterogeneity
  • Metabolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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