@inbook{518d2b77a977465c988b5d018acec530,
title = "The intratumoral heterogeneity of cancer metabolism",
abstract = "Heterogeneity is a hallmark of cancer.Clonal evolution theory and cancer stem cell theory explain tumor subpopulation growth.Intratumoral metabolism heterogeneity follows intratumoral genetics alterations.Epigenetics alterations lead to intratumoral metabolism heterogeneity.Intratumoral metabolic adaptation and heterogeneity are due to the intemperate conditions of the tumor microenvironment.Spatial and temporal heterogeneity provides survival advantages to tumors.Metabolic profile-targeted therapeutics can result in successful clinical outcomes.",
keywords = "Angiogenesis, Genetic and metabolic adaptation, Hypoxia, Intratumoral heterogeneity, Metabolism",
author = "Karim Nabi and Anne Le",
note = "Publisher Copyright: {\textcopyright} 2018, Springer International Publishing AG, part of Springer Nature.",
year = "2018",
doi = "10.1007/978-3-319-77736-8_10",
language = "English (US)",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "131--145",
booktitle = "Advances in Experimental Medicine and Biology",
}