The intracellular life of Cryptococcus neoformans

Carolina Coelho, Anamelia L. Bocca, Arturo Casadevall

Research output: Contribution to journalArticlepeer-review

Abstract

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological studies of human populations show a high prevalence of human infection, which rarely progresses to disease in immunocompetent hosts. However, decreased host immunity places individuals at high risk for cryptococcal disease. The disease can result from acute infection or reactivation of latent infection, in which yeasts within granulomas and host macrophages emerge to cause disease. In this review, we summarize what is known about the cellular recognition, ingestion, and killing of C. neoformans and discuss the unique and remarkable features of its intracellular life, including the proposed mechanisms for fungal persistence and killing in phagocytic cells.

Original languageEnglish (US)
Pages (from-to)219-238
Number of pages20
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume9
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • C. neoformans killing
  • Disease tolerance
  • Fungal immunity
  • Granuloma
  • Intracellular pathogen
  • Trojan horse

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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