The interval-force relationship: A technique for evaluating the cardiac toxicity of anthracycline analogs

J. G S Breed, A. N E Zimmerman, F. L. Meyler, H. M. Pinedo

Research output: Contribution to journalArticle

Abstract

The most serious side effect of the anthracycline derivatives is dose-related cardiac toxicity induced during repeated administration. An in vitro method is described which assesses the interval-force relationship in evaluating the contractility of the rat and rabbit heart. Repeated administration of Adriamycin resulted in a progressive decrease in contractility which correlated closely with the cumulative dose administered. This model offers a reliable method to evaluate the effect of new anthracycline analogs on the heart and to study the potential of other drugs or agents to protect against cardiac toxicity.

Original languageEnglish (US)
Pages (from-to)869-873
Number of pages5
JournalCancer Treatment Reports
Volume63
Issue number5
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Breed, J. G. S., Zimmerman, A. N. E., Meyler, F. L., & Pinedo, H. M. (1979). The interval-force relationship: A technique for evaluating the cardiac toxicity of anthracycline analogs. Cancer Treatment Reports, 63(5), 869-873.