The interval-force relationship: A technique for evaluating the cardiac toxicity of anthracycline analogs

J. G S Breed; A. N E Zimmerman; F. L. Meyler; H. M. Pinedo

The interval-force relationship: A technique for evaluating the cardiac toxicity of anthracycline analogs

J. G S Breed, A. N E Zimmerman, F. L. Meyler, H. M. Pinedo

Research output: Contribution to journal › Article › peer-review

Abstract

The most serious side effect of the anthracycline derivatives is dose-related cardiac toxicity induced during repeated administration. An in vitro method is described which assesses the interval-force relationship in evaluating the contractility of the rat and rabbit heart. Repeated administration of Adriamycin resulted in a progressive decrease in contractility which correlated closely with the cumulative dose administered. This model offers a reliable method to evaluate the effect of new anthracycline analogs on the heart and to study the potential of other drugs or agents to protect against cardiac toxicity.

Original language	English (US)
Pages (from-to)	869-873
Number of pages	5
Journal	Cancer Treatment Reports
Volume	63
Issue number	5
State	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

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abstract = "The most serious side effect of the anthracycline derivatives is dose-related cardiac toxicity induced during repeated administration. An in vitro method is described which assesses the interval-force relationship in evaluating the contractility of the rat and rabbit heart. Repeated administration of Adriamycin resulted in a progressive decrease in contractility which correlated closely with the cumulative dose administered. This model offers a reliable method to evaluate the effect of new anthracycline analogs on the heart and to study the potential of other drugs or agents to protect against cardiac toxicity.",

author = "Breed, {J. G S} and Zimmerman, {A. N E} and Meyler, {F. L.} and Pinedo, {H. M.}",

year = "1979",

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AU - Pinedo, H. M.

PY - 1979

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N2 - The most serious side effect of the anthracycline derivatives is dose-related cardiac toxicity induced during repeated administration. An in vitro method is described which assesses the interval-force relationship in evaluating the contractility of the rat and rabbit heart. Repeated administration of Adriamycin resulted in a progressive decrease in contractility which correlated closely with the cumulative dose administered. This model offers a reliable method to evaluate the effect of new anthracycline analogs on the heart and to study the potential of other drugs or agents to protect against cardiac toxicity.

AB - The most serious side effect of the anthracycline derivatives is dose-related cardiac toxicity induced during repeated administration. An in vitro method is described which assesses the interval-force relationship in evaluating the contractility of the rat and rabbit heart. Repeated administration of Adriamycin resulted in a progressive decrease in contractility which correlated closely with the cumulative dose administered. This model offers a reliable method to evaluate the effect of new anthracycline analogs on the heart and to study the potential of other drugs or agents to protect against cardiac toxicity.

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The interval-force relationship: A technique for evaluating the cardiac toxicity of anthracycline analogs

Abstract

ASJC Scopus subject areas

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