The interplay of microRNA and neuronal activity in health and disease

Research output: Contribution to journalReview articlepeer-review

Abstract

MicroRNAs (miRNAs) are small 19-23 nucleotide regulatory RNAs that function by modulating mRNA translation and/or turnover in a sequence-specific fashion. In the nervous system, miRNAs regulate the production of numerous proteins involved in synaptic transmission. In turn, neuronal activity can regulate the production and turnover of miRNA through a variety of mechanisms. In this way, miRNAs and neuronal activity are in a reciprocal homeostatic relationship that balances neuronal function. The miRNA function is critical in pathological states related to overexcitation such as epilepsy and stroke, suggesting miRNA's potential as a therapeutic target. We review the current literature relating the interplay of miRNA and neuronal activity and provide future directions for defining miRNA's role in disease.

Original languageEnglish (US)
Article number136
JournalFrontiers in Cellular Neuroscience
Issue numberAUG
DOIs
StatePublished - Aug 27 2013

Keywords

  • Epilepsy
  • Neuroprotective agents
  • Stroke
  • Synaptic plasticity
  • microRNA

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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