The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: Apoptosis meets autophagy

Anne Hamacher-Brady, Nathan Ryan Brady, Roberta Anne Gottlieb

Research output: Contribution to journalReview article

Abstract

Introduction: Programmed cell death of cardiac myocytes occurs following a bout of ischemia/reperfusion (I/R), which results in reduced function of the heart. Numerous studies, including in vivo, have shown that cell death occurs via necrosis and apoptosis following I/R. Recently, autophagy has emerged as a powerful mediator of programmed cell death, either opposing or enhancing apoptosis, or acting as an alternative form of programmed cell death distinct from apoptosis. Aim: Here we review the apoptotic and autophagic signaling pathways, their influences on each other, and we discuss the relevance of autophagy in the heart.

Original languageEnglish (US)
Pages (from-to)445-462
Number of pages18
JournalCardiovascular Drugs and Therapy
Volume20
Issue number6
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

Keywords

  • Apoptosis
  • Autophagy
  • GFP-LC3
  • Mitochondria

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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