The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder

Knowledge to date and directions for future research

Benjamin I. Goldstein, Boris Birmaher, Gabrielle A. Carlson, Melissa P. Delbello, Robert L Findling, Mary Fristad, Robert A. Kowatch, David J. Miklowitz, Fabiano G. Nery, Guillermo Perez-Algorta, Anna Van Meter, Cristian P. Zeni, Christoph U. Correll, Hyo Won Kim, Janet Wozniak, Kiki D. Chang, Manon Hillegers, Eric A. Youngstrom

Research output: Contribution to journalArticle

Abstract

Objectives: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. Methods: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps. Results: Substantial, and increasingly international, research has accumulated regarding the phenomenology, differential diagnosis, course, treatment, and neurobiology of PBD. Prior division around the role of irritability and of screening tools in diagnosis has largely abated. Gold-standard pharmacologic trials inform treatment of manic/mixed episodes, whereas fewer data address bipolar depression and maintenance/continuation treatment. Adjunctive psychosocial treatment provides a forum for psychoeducation and targets primarily depressive symptoms. Numerous neurocognitive and neuroimaging studies, and increasing peripheral biomarker studies, largely converge with prior findings from adults with BD. Conclusions: As data have accumulated and controversy has dissipated, the field has moved past existential questions about PBD toward defining and pursuing pressing clinical and scientific priorities that remain. The overall body of evidence supports the position that perceptions about marked international (US vs elsewhere) and developmental (pediatric vs adult) differences have been overstated, although additional research on these topics is warranted. Traction toward improved outcomes will be supported by continued emphasis on pathophysiology and novel therapeutics.

Original languageEnglish (US)
JournalBipolar Disorders
DOIs
StateAccepted/In press - 2017

Fingerprint

Advisory Committees
Bipolar Disorder
Pediatrics
Research
Therapeutics
Neurobiology
Traction
Neuroimaging
Gold
Consensus
Differential Diagnosis
Biomarkers
Maintenance
Direction compound
Depression
Growth

Keywords

  • Adolescent
  • Bipolar disorder
  • Child
  • Pediatric
  • Youth

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder : Knowledge to date and directions for future research. / Goldstein, Benjamin I.; Birmaher, Boris; Carlson, Gabrielle A.; Delbello, Melissa P.; Findling, Robert L; Fristad, Mary; Kowatch, Robert A.; Miklowitz, David J.; Nery, Fabiano G.; Perez-Algorta, Guillermo; Van Meter, Anna; Zeni, Cristian P.; Correll, Christoph U.; Kim, Hyo Won; Wozniak, Janet; Chang, Kiki D.; Hillegers, Manon; Youngstrom, Eric A.

In: Bipolar Disorders, 2017.

Research output: Contribution to journalArticle

Goldstein, BI, Birmaher, B, Carlson, GA, Delbello, MP, Findling, RL, Fristad, M, Kowatch, RA, Miklowitz, DJ, Nery, FG, Perez-Algorta, G, Van Meter, A, Zeni, CP, Correll, CU, Kim, HW, Wozniak, J, Chang, KD, Hillegers, M & Youngstrom, EA 2017, 'The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research', Bipolar Disorders. https://doi.org/10.1111/bdi.12556
Goldstein, Benjamin I. ; Birmaher, Boris ; Carlson, Gabrielle A. ; Delbello, Melissa P. ; Findling, Robert L ; Fristad, Mary ; Kowatch, Robert A. ; Miklowitz, David J. ; Nery, Fabiano G. ; Perez-Algorta, Guillermo ; Van Meter, Anna ; Zeni, Cristian P. ; Correll, Christoph U. ; Kim, Hyo Won ; Wozniak, Janet ; Chang, Kiki D. ; Hillegers, Manon ; Youngstrom, Eric A. / The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder : Knowledge to date and directions for future research. In: Bipolar Disorders. 2017.
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T2 - Knowledge to date and directions for future research

AU - Goldstein, Benjamin I.

AU - Birmaher, Boris

AU - Carlson, Gabrielle A.

AU - Delbello, Melissa P.

AU - Findling, Robert L

AU - Fristad, Mary

AU - Kowatch, Robert A.

AU - Miklowitz, David J.

AU - Nery, Fabiano G.

AU - Perez-Algorta, Guillermo

AU - Van Meter, Anna

AU - Zeni, Cristian P.

AU - Correll, Christoph U.

AU - Kim, Hyo Won

AU - Wozniak, Janet

AU - Chang, Kiki D.

AU - Hillegers, Manon

AU - Youngstrom, Eric A.

PY - 2017

Y1 - 2017

N2 - Objectives: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. Methods: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps. Results: Substantial, and increasingly international, research has accumulated regarding the phenomenology, differential diagnosis, course, treatment, and neurobiology of PBD. Prior division around the role of irritability and of screening tools in diagnosis has largely abated. Gold-standard pharmacologic trials inform treatment of manic/mixed episodes, whereas fewer data address bipolar depression and maintenance/continuation treatment. Adjunctive psychosocial treatment provides a forum for psychoeducation and targets primarily depressive symptoms. Numerous neurocognitive and neuroimaging studies, and increasing peripheral biomarker studies, largely converge with prior findings from adults with BD. Conclusions: As data have accumulated and controversy has dissipated, the field has moved past existential questions about PBD toward defining and pursuing pressing clinical and scientific priorities that remain. The overall body of evidence supports the position that perceptions about marked international (US vs elsewhere) and developmental (pediatric vs adult) differences have been overstated, although additional research on these topics is warranted. Traction toward improved outcomes will be supported by continued emphasis on pathophysiology and novel therapeutics.

AB - Objectives: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. Methods: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps. Results: Substantial, and increasingly international, research has accumulated regarding the phenomenology, differential diagnosis, course, treatment, and neurobiology of PBD. Prior division around the role of irritability and of screening tools in diagnosis has largely abated. Gold-standard pharmacologic trials inform treatment of manic/mixed episodes, whereas fewer data address bipolar depression and maintenance/continuation treatment. Adjunctive psychosocial treatment provides a forum for psychoeducation and targets primarily depressive symptoms. Numerous neurocognitive and neuroimaging studies, and increasing peripheral biomarker studies, largely converge with prior findings from adults with BD. Conclusions: As data have accumulated and controversy has dissipated, the field has moved past existential questions about PBD toward defining and pursuing pressing clinical and scientific priorities that remain. The overall body of evidence supports the position that perceptions about marked international (US vs elsewhere) and developmental (pediatric vs adult) differences have been overstated, although additional research on these topics is warranted. Traction toward improved outcomes will be supported by continued emphasis on pathophysiology and novel therapeutics.

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KW - Child

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KW - Youth

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