The international nuclear workers study (INWORKS): A collaborative epidemiological study to improve knowledge about health effects of protracted low-dose exposure

Dominique Laurier, David B. Richardson, Elisabeth Cardis, Robert D. Daniels, Michael Gillies, Jackie O'Hagan, Ghassan Hamra, Richard Haylock, Klervi Leuraud, Monika Moissonnier, Mary K. Schubauer-Berigan, Isabelle Thierry-Chef, Ausrele Kesminiene

Research output: Contribution to journalArticle

Abstract

INWORKS is a multinational cohort study, gathering 308 297 workers in the nuclear industry in France, the United Kingdom and the United States of America, with detailed individual monitoring data for external exposure to ionising radiation. Over a mean duration of follow-up of 27 y, the number of observed deaths was 66 632, including 17 957 deaths due to solid cancers, 1791 deaths due to haematological cancers and 27 848 deaths due to cardiovascular diseases. Mean individual cumulative external dose over the period 1945-2005 was 25 mSv. Analyses demonstrated a significant association between red bone marrow dose and the risk of leukaemia (excluding chronic lymphocytic leukaemia) and between colon dose and the risk of solid cancers. INWORKS assembled some of the strongest evidence to strengthen the scientific basis for the protection of adults from low dose, low-dose rate, exposures to ionising radiation.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalRadiation Protection Dosimetry
Volume173
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Public Health, Environmental and Occupational Health

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    Laurier, D., Richardson, D. B., Cardis, E., Daniels, R. D., Gillies, M., O'Hagan, J., Hamra, G., Haylock, R., Leuraud, K., Moissonnier, M., Schubauer-Berigan, M. K., Thierry-Chef, I., & Kesminiene, A. (2017). The international nuclear workers study (INWORKS): A collaborative epidemiological study to improve knowledge about health effects of protracted low-dose exposure. Radiation Protection Dosimetry, 173(1), 21-25. https://doi.org/10.1093/rpd/ncw314