The interface of lung volume reduction surgery and lung transplantation

Research output: Chapter in Book/Report/Conference proceedingChapter


The first human lung transplant is credited to Hardy and colleagues (1), who performed this procedure in 1963. The patient suffered from emphysema and lung cancer and would not have survived resection without transplantation. Unfortunately, the patient died on the 18th postoperative day, raising questions about the utility of this procedure. Nearly 20 years passed before lung transplantation was finally successful. With significant improvement in survival and functional outcomes since Hardy’s first attempt, this procedure is now a widely accepted therapeutic option for patients with end-stage lung disease (2). As with other solid organ transplants, the success of lung transplantation followed the introduction of the immunosuppressive drug cyclosporine A in the early 1980s (3). Since then, with some modifications to the surgical technique, lung transplantation is now performed routinely to prolong the life and functional capabilities of patients with end-stage lung disorders.

Original languageEnglish (US)
Title of host publicationLung Volume Reduction Surgery for Emphysema
PublisherCRC Press
Number of pages18
ISBN (Electronic)9780824757748
ISBN (Print)9780824708979
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Medicine(all)


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