TY - JOUR
T1 - The interaction of the ubiquitin 50-59 fragment with copper(II) ions
AU - Czapor-Irzabek, Hanna
AU - Cebrat, Marek
AU - Czyznikowska, Zaneta
AU - Brasuń, Justyna
PY - 2012/5
Y1 - 2012/5
N2 - In the present study, the coordination abilities of ubiquitin 50-59 fragment and its analog containing βAsp residue are discussed. The analysis is provided based on the results of potentiometric and spectroscopic measurements supported by quantum-chemical calculations. Interesting differences in the coordination of the metal cation by modified and unmodified peptides are reported. Moreover, in order to further characterize experimentally observed species, we performed quantum-chemical calculations for structures mimicking ubiquitin 50-59 fragment as a step toward a better understanding of structural and energetical aspects related to the coordination abilities of ubiquitin.
AB - In the present study, the coordination abilities of ubiquitin 50-59 fragment and its analog containing βAsp residue are discussed. The analysis is provided based on the results of potentiometric and spectroscopic measurements supported by quantum-chemical calculations. Interesting differences in the coordination of the metal cation by modified and unmodified peptides are reported. Moreover, in order to further characterize experimentally observed species, we performed quantum-chemical calculations for structures mimicking ubiquitin 50-59 fragment as a step toward a better understanding of structural and energetical aspects related to the coordination abilities of ubiquitin.
KW - Copper(II) complexes
KW - Peptides
KW - Ubiquitin
UR - http://www.scopus.com/inward/record.url?scp=84858967540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858967540&partnerID=8YFLogxK
U2 - 10.1016/j.jinorgbio.2011.11.001
DO - 10.1016/j.jinorgbio.2011.11.001
M3 - Article
C2 - 22459166
AN - SCOPUS:84858967540
VL - 110
SP - 40
EP - 45
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
SN - 0162-0134
ER -