The interaction of the ubiquitin 50-59 fragment with copper(II) ions

Hanna Czapor-Irzabek, Marek Cebrat, Zaneta Czyznikowska, Justyna Brasuń

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, the coordination abilities of ubiquitin 50-59 fragment and its analog containing βAsp residue are discussed. The analysis is provided based on the results of potentiometric and spectroscopic measurements supported by quantum-chemical calculations. Interesting differences in the coordination of the metal cation by modified and unmodified peptides are reported. Moreover, in order to further characterize experimentally observed species, we performed quantum-chemical calculations for structures mimicking ubiquitin 50-59 fragment as a step toward a better understanding of structural and energetical aspects related to the coordination abilities of ubiquitin.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume110
DOIs
StatePublished - May 2012
Externally publishedYes

Keywords

  • Copper(II) complexes
  • Peptides
  • Ubiquitin

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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