The interaction of natural and synthetic polyanions with mammalian nuclei. II. Nuclear swelling

Richard J. Kraemer, Donald S. Coffey

Research output: Contribution to journalArticle

Abstract

Various types of polyanions were tested for their effects on nuclear swelling using a new spectrophotometric technique. Heparin, dextran sulfate and polyaspartic acids (20 000-35 000 mol. wt.) caused nuclear swelling whereas polygalacturonic acid, chondroitin sulfate, hyaluronic acid, aspartic acid and polyaspartic acid (5600 mol. wt.) showed no swelling activity. The specificity of the polyanions for nuclear swelling was correlated with their effects on the template activity of nuclear DNA and chromatin during DNA synthesis.

Original languageEnglish (US)
Pages (from-to)568-578
Number of pages11
JournalBBA Section Nucleic Acids And Protein Synthesis
Volume224
Issue number2
DOIs
StatePublished - Dec 14 1970

ASJC Scopus subject areas

  • Medicine(all)

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