TY - JOUR
T1 - The intensive care delirium research agenda
T2 - a multinational, interprofessional perspective
AU - Pandharipande, Pratik P.
AU - Ely, E. Wesley
AU - Arora, Rakesh C.
AU - Balas, Michele C.
AU - Boustani, Malaz A.
AU - La Calle, Gabriel Heras
AU - Cunningham, Colm
AU - Devlin, John W.
AU - Elefante, Julius
AU - Han, Jin H.
AU - MacLullich, Alasdair M.
AU - Maldonado, José R.
AU - Morandi, Alessandro
AU - Needham, Dale M.
AU - Page, Valerie J.
AU - Rose, Louise
AU - Salluh, Jorge I.F.
AU - Sharshar, Tarek
AU - Shehabi, Yahya
AU - Skrobik, Yoanna
AU - Slooter, Arjen J.C.
AU - Smith, Heidi A.B.
N1 - Publisher Copyright:
© 2017, Springer-Verlag GmbH Germany and ESICM.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Delirium, a prevalent organ dysfunction in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy, and the neurosciences sought to address five questions: (1) What is the current standard of care in managing ICU delirium? (2) What have been the major recent advances in delirium research and care? (3) What are the common delirium beliefs that have been challenged by recent trials? (4) What are the remaining areas of uncertainty in delirium research? (5) What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium, identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda.
AB - Delirium, a prevalent organ dysfunction in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy, and the neurosciences sought to address five questions: (1) What is the current standard of care in managing ICU delirium? (2) What have been the major recent advances in delirium research and care? (3) What are the common delirium beliefs that have been challenged by recent trials? (4) What are the remaining areas of uncertainty in delirium research? (5) What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium, identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda.
KW - Cognitive impairment
KW - Delirium
KW - Research agenda
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U2 - 10.1007/s00134-017-4860-7
DO - 10.1007/s00134-017-4860-7
M3 - Review article
C2 - 28612089
AN - SCOPUS:85020708226
SN - 0342-4642
VL - 43
SP - 1329
EP - 1339
JO - Intensive Care Medicine
JF - Intensive Care Medicine
IS - 9
ER -