TY - JOUR
T1 - The intensive care delirium research agenda
T2 - a multinational, interprofessional perspective
AU - Pandharipande, Pratik P.
AU - Ely, E. Wesley
AU - Arora, Rakesh C.
AU - Balas, Michele C.
AU - Boustani, Malaz A.
AU - La Calle, Gabriel Heras
AU - Cunningham, Colm
AU - Devlin, John W.
AU - Elefante, Julius
AU - Han, Jin H.
AU - MacLullich, Alasdair M.
AU - Maldonado, José R.
AU - Morandi, Alessandro
AU - Needham, Dale M.
AU - Page, Valerie J.
AU - Rose, Louise
AU - Salluh, Jorge I.F.
AU - Sharshar, Tarek
AU - Shehabi, Yahya
AU - Skrobik, Yoanna
AU - Slooter, Arjen J.C.
AU - Smith, Heidi A.B.
N1 - Funding Information:
Dr. Pandharipande has a research grant from Hospira Inc. Dr. Ely has received research grants and/or honoraria from Hospira, Orion, Pfizer, and Abbott. Dr. Arora has an unrestricted education grant from Pfizer Canada and received honoraria from Mallinckrodt Pharmaceutical. Dr. Devlin has received a research grant from AstraZeneca Pharmaceuticals. Dr. Page has received honoraria from Orion Pharma, UK. Prof. A. J. C. Slooter works on the development of an EEG-based delirium monitor, any (future) profits of this technology will be used for future scientific research only. Dr. Shehabi has received related unrestricted research and educational from Hospira Inc, Pfizer and Orion Pharma. Speaker honorarium and travel expenses reimbursed to employing institution.
Funding Information:
Dr. Pandharipande (R01HL111111 and R01AG035117) and Dr. Needham (R24HL111895 and R24AG054259) are supported by the National Institutes of Health. Dr. Ely is supported by the National Institutes of Health (R01AG035117 and R01HL111111) and the VA GRECC. Prof. A. J. C. Slooter is supported by the European Society of Intensive Care Medicine, Technology Foundation STW (14066) and the European Union (H2020-PHC-12-2014-672974). Dr. Devlin is supported by the National Institutes of Health (1R21G04567212). Dr. Shehabi is supported by a National Health and Medical Research Council of Australia project grant (APP1043938).
Publisher Copyright:
© 2017, Springer-Verlag GmbH Germany and ESICM.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Delirium, a prevalent organ dysfunction in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy, and the neurosciences sought to address five questions: (1) What is the current standard of care in managing ICU delirium? (2) What have been the major recent advances in delirium research and care? (3) What are the common delirium beliefs that have been challenged by recent trials? (4) What are the remaining areas of uncertainty in delirium research? (5) What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium, identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda.
AB - Delirium, a prevalent organ dysfunction in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy, and the neurosciences sought to address five questions: (1) What is the current standard of care in managing ICU delirium? (2) What have been the major recent advances in delirium research and care? (3) What are the common delirium beliefs that have been challenged by recent trials? (4) What are the remaining areas of uncertainty in delirium research? (5) What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium, identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda.
KW - Cognitive impairment
KW - Delirium
KW - Research agenda
UR - http://www.scopus.com/inward/record.url?scp=85020708226&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020708226&partnerID=8YFLogxK
U2 - 10.1007/s00134-017-4860-7
DO - 10.1007/s00134-017-4860-7
M3 - Review article
C2 - 28612089
AN - SCOPUS:85020708226
VL - 43
SP - 1329
EP - 1339
JO - Intensive Care Medicine
JF - Intensive Care Medicine
SN - 0342-4642
IS - 9
ER -