@article{7a7b491c767e48adb8a07103ffed4601,
title = "The integrin receptor α8β1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C",
abstract = "This paper identifies a neuronal receptor for tenascin-C (tenascin/cytotactin), an extracellular matrix protein that has previously been detected in developing sensory and motor neuron pathways and has been shown to regulate cell migration in the developing CNS. Antibodies specific for each subunit of the integrin asp, are used to demonstrate that α8β1 mediates neurite outgrowth of embryonic sensory and motor neurons on this extracellular matrix protein. In addition, expression of α8 in K562 cells results in surface expression of α8β1 heterodimers that are shown to promote attachment of this cell line to tenascin. The major domain in tenascin that mediates neurite outgrowth is shown to be localized to fibronectin type III repeats 6-8.",
author = "Barbara Varnum-Finney and Kristine Venstrom and Ulrich Muller and Robert Kypta and Carey Backus and Matthias Chiquet and Reichardt, {Louis F.}",
note = "Funding Information: All correspondence should be addressed to L. F. R. We thank Dr. Blaise Bossy for assistance in preparing the ~8-transfected K562 cell lines and the anti-~8-EX antibody, Dr. Susannah Chang for the DM1 MAb, Dr. Karla Neugebauer for helping to develop the tenascin purification, and Ms. Cristina Weaver for reading the manuscript and for helpful discussions. This work was supported by National Institutes of Health grant PO1-16033. L. F. R. is an investigator of the Howard Hughes Medical Institute. The costs of publication of this article were defrayed in part by the payment of page charges. This artcle must therefore be hereby marked {"}advertisement{"} in accordance with 18 USC Section 1734 solely to indicate this fact.",
year = "1995",
month = jun,
doi = "10.1016/0896-6273(95)90268-6",
language = "English (US)",
volume = "14",
pages = "1213--1222",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",
}