The integration of primary anorexia nervosa and obsessive-compulsive disorder

J. A. Yaryura-Tobias, A. Pinto, F. Neziroglu

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


This paper explores the relationship between primary anorexia nervosa (PAN) and obsessive-compulsive disorder (OCD) in both their concomitant and their sequential presentation. Their clinical descriptions demonstrate the presence of obsessionality and compul-siveness that seem to interface during their course and overlap in their symptomatologies has been noted for over sixty years. However, recent research in this regard is scant. Commonalities in pathophysiology indicate disturbances in neurotransmitters, notably sero-tonin. Biological challenges have failed to establish a definitive correlation with PAN and OCD, whether in combination or individually. We may postulate that, with limitations, they share some anatomical pathways. The areas affected are the amygdala, cingulum and orbito-frontal cortex. Few studies, however, have been devoted to the treatment of concomitant PAN and OCD.

Original languageEnglish (US)
Pages (from-to)174-180
Number of pages7
JournalEating and Weight Disorders
Issue number4
StatePublished - Dec 2001
Externally publishedYes


  • Comorbidity
  • Obsessive-compulsive disorder
  • Primary anorexia nervosa
  • Serotonin

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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