TY - JOUR
T1 - The Integrated Project ReProTect
T2 - A novel approach in reproductive toxicity hazard assessment
AU - Hareng, Lars
AU - Pellizzer, Cristian
AU - Bremer, Susanne
AU - Schwarz, Michael
AU - Hartung, Thomas
PY - 2005/9
Y1 - 2005/9
N2 - Validated alternative test methods are urgently needed for safety testing of drugs, chemicals and cosmetics. Whereas some animal tests for topical toxicity have been successfully replaced by alternative methods, systemic toxicity testing requires new test strategies in order to achieve an adequate safety level for the consumer. Substantial numbers of animals are required for the current in vivo assays for drugs, chemicals and cosmetics and a broad range of pioneering alternative methods were already developed. These prerequisites motivate the development of a tiered testing strategy based on alternative tests for reproductive toxicity hazard. In the Integrated Project ReProTect, a consortium set up by the European Centre for the Validation of Alternative Methods (ECVAM) takes the lead to manage the development of a testing strategy in the area of reproductive toxicity. The reproductive cycle can be broken down into well-defined sub-elements, namely male and female fertility, implantation and pre/postnatal development. In this project, in vitro, in silico and sensor technologies will be developed, leading to testing strategies, that shall be implemented and disseminated.
AB - Validated alternative test methods are urgently needed for safety testing of drugs, chemicals and cosmetics. Whereas some animal tests for topical toxicity have been successfully replaced by alternative methods, systemic toxicity testing requires new test strategies in order to achieve an adequate safety level for the consumer. Substantial numbers of animals are required for the current in vivo assays for drugs, chemicals and cosmetics and a broad range of pioneering alternative methods were already developed. These prerequisites motivate the development of a tiered testing strategy based on alternative tests for reproductive toxicity hazard. In the Integrated Project ReProTect, a consortium set up by the European Centre for the Validation of Alternative Methods (ECVAM) takes the lead to manage the development of a testing strategy in the area of reproductive toxicity. The reproductive cycle can be broken down into well-defined sub-elements, namely male and female fertility, implantation and pre/postnatal development. In this project, in vitro, in silico and sensor technologies will be developed, leading to testing strategies, that shall be implemented and disseminated.
KW - Developmental toxicity
KW - ECVAM
KW - Hazard assessment
KW - Integrated Project ReProTect
KW - Reproductive toxicity
UR - http://www.scopus.com/inward/record.url?scp=21744435739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21744435739&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2005.04.003
DO - 10.1016/j.reprotox.2005.04.003
M3 - Review article
C2 - 15899576
AN - SCOPUS:21744435739
SN - 0890-6238
VL - 20
SP - 441
EP - 452
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 3
ER -