The insula-claustrum region and delusions in schizophrenia

Nicola G. Cascella; Gwendolyn J. Gerner; Shaina C. Fieldstone; Akira Sawa; David J. Schretlen

doi:10.1016/j.schres.2011.08.004

The insula-claustrum region and delusions in schizophrenia

Nicola G. Cascella, Gwendolyn J. Gerner, Shaina C. Fieldstone, Akira Sawa, David J. Schretlen

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Objective: We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. Method: MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions. Results: The analysis revealed significant inverse correlations between ratings of the severity of delusions and volumes of the left claustrum and right insula. Significant correlations were not observed between cerebral GM volume and ratings of hallucinations. Conclusion: The insula/claustrum region may be critical to the experience of delusions and more careful scrutiny of the claustrum in relation to schizophrenia appears warranted.

Original language	English (US)
Pages (from-to)	77-81
Number of pages	5
Journal	Schizophrenia Research
Volume	133
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2011.08.004
State	Published - Dec 2011

Keywords

Cerebral gray matter
Claustrum
Positive symptoms

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2011.08.004

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title = "The insula-claustrum region and delusions in schizophrenia",

abstract = "Objective: We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. Method: MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions. Results: The analysis revealed significant inverse correlations between ratings of the severity of delusions and volumes of the left claustrum and right insula. Significant correlations were not observed between cerebral GM volume and ratings of hallucinations. Conclusion: The insula/claustrum region may be critical to the experience of delusions and more careful scrutiny of the claustrum in relation to schizophrenia appears warranted.",

keywords = "Cerebral gray matter, Claustrum, Positive symptoms",

author = "Cascella, {Nicola G.} and Gerner, {Gwendolyn J.} and Fieldstone, {Shaina C.} and Akira Sawa and Schretlen, {David J.}",

note = "Funding Information: This work was supported by Stanley Medical Research Institute (SMRI) grant (N.G.C.). The funding source had no role in study design, analysis and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication. ",

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AU - Cascella, Nicola G.

AU - Gerner, Gwendolyn J.

AU - Fieldstone, Shaina C.

AU - Sawa, Akira

AU - Schretlen, David J.

N1 - Funding Information: This work was supported by Stanley Medical Research Institute (SMRI) grant (N.G.C.). The funding source had no role in study design, analysis and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication.

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N2 - Objective: We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. Method: MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions. Results: The analysis revealed significant inverse correlations between ratings of the severity of delusions and volumes of the left claustrum and right insula. Significant correlations were not observed between cerebral GM volume and ratings of hallucinations. Conclusion: The insula/claustrum region may be critical to the experience of delusions and more careful scrutiny of the claustrum in relation to schizophrenia appears warranted.

AB - Objective: We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. Method: MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions. Results: The analysis revealed significant inverse correlations between ratings of the severity of delusions and volumes of the left claustrum and right insula. Significant correlations were not observed between cerebral GM volume and ratings of hallucinations. Conclusion: The insula/claustrum region may be critical to the experience of delusions and more careful scrutiny of the claustrum in relation to schizophrenia appears warranted.

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The insula-claustrum region and delusions in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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