The ins and outs of EGFR asymmetry

Daniel J. Leahy

Research output: Contribution to journalShort surveypeer-review


The epidermal growth factor receptor (EGFR) regulates cell proliferation in many tissues. A new structure of the Drosophila EGFR presented by Alvarado et al. (2010) reveals an asymmetric dimer with the ligand bound to only one subunit. The structure provides a rationale for the receptor's negative cooperativity and necessitates a reconsideration of models for activation of human EGFR.

Original languageEnglish (US)
Pages (from-to)513-515
Number of pages3
Issue number4
StatePublished - Aug 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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