The innate immune response in ischemic acute kidney injury

Hye Ryoun Jang, Hamid Rabb

Research output: Contribution to journalReview article

Abstract

Kidney ischemia reperfusion injury is a major cause of morbidity in both allograft and native kidneys. Ischemia reperfusion-induced acute kidney injury is characterized by early, alloantigen-independent inflammation. Major components of the innate immune system are activated and participate in the pathogenesis of acute kidney injury, plus prime the allograft kidney for rejection. Soluble members of innate immunity implicated in acute kidney injury include the complement system, cytokines, and chemokines. Toll-like receptors (TLRs) are also important contributors. Effector cells that participate in acute kidney injury include the classic innate immune cells, neutrophils and macrophages. Recent data has unexpectedly identified lymphocytes as participants of early acute kidney injury responses. In this review, we will focus on immune mediators that participate in the pathogenesis of ischemic acute kidney injury.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalClinical Immunology
Volume130
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • Inflammation
  • Innate immunity
  • Ischemia reperfusion injury

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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