The innate immune response in ischemic acute kidney injury

Hye Ryoun Jang, Hamid Rabb

Research output: Contribution to journalArticle

Abstract

Kidney ischemia reperfusion injury is a major cause of morbidity in both allograft and native kidneys. Ischemia reperfusion-induced acute kidney injury is characterized by early, alloantigen-independent inflammation. Major components of the innate immune system are activated and participate in the pathogenesis of acute kidney injury, plus prime the allograft kidney for rejection. Soluble members of innate immunity implicated in acute kidney injury include the complement system, cytokines, and chemokines. Toll-like receptors (TLRs) are also important contributors. Effector cells that participate in acute kidney injury include the classic innate immune cells, neutrophils and macrophages. Recent data has unexpectedly identified lymphocytes as participants of early acute kidney injury responses. In this review, we will focus on immune mediators that participate in the pathogenesis of ischemic acute kidney injury.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalClinical Immunology
Volume130
Issue number1
DOIs
StatePublished - Jan 2009

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Acute Kidney Injury
Innate Immunity
Kidney
Allografts
Isoantigens
Toll-Like Receptors
Reperfusion Injury
Chemokines
Reperfusion
Immune System
Neutrophils
Ischemia
Macrophages
Lymphocytes
Cytokines
Inflammation
Morbidity

Keywords

  • Inflammation
  • Innate immunity
  • Ischemia reperfusion injury

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The innate immune response in ischemic acute kidney injury. / Jang, Hye Ryoun; Rabb, Hamid.

In: Clinical Immunology, Vol. 130, No. 1, 01.2009, p. 41-50.

Research output: Contribution to journalArticle

Jang, Hye Ryoun ; Rabb, Hamid. / The innate immune response in ischemic acute kidney injury. In: Clinical Immunology. 2009 ; Vol. 130, No. 1. pp. 41-50.
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