The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism

R. W. Downs, R. D. Sekura, M. A. Levine, A. M. Spiegel

Research output: Contribution to journalArticle

Abstract

Deficient activity of the adenylate cyclase stimulatory coupling protein (N(s)) has been demonstrated in many patients with pseudohypoparathyroidism type I (PHP) who have Albright's hereditary osteodystrophy and multiple hormone resistance. Since an abnormality in the activity of the related adenylate cyclase inhibitory coupling protein (N(i)) could influence hormone responsiveness, we measured pertussis toxin-catalyzed [32P]ADP ribosylation of the 40,000-dalton α-subunit of N(i) (N(i)α) in erythrocyte membranes from patients with PHP and normal subjects. There were no significant differences in the amounts of N(i)α in membranes from normal subjects, patients with PHP who have low N(s) associated with Albright's hereditary osteodystrophy and multiple hormone resistance, and patients with PHP who have normal N(s). Abnormal N(i) is not likely to cause hormone resistance in patients with PHP who have normal N(s) to influence hormone responsiveness in patients with PHP who have low N(s).

Original languageEnglish (US)
Pages (from-to)351-354
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume61
Issue number2
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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  • Cite this

    Downs, R. W., Sekura, R. D., Levine, M. A., & Spiegel, A. M. (1985). The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism. Journal of Clinical Endocrinology and Metabolism, 61(2), 351-354.