TY - JOUR
T1 - The Influence of Structural Abnormality on Ion Transport in Rabbit Ileum 35103
AU - Al-Awqati, Qais
AU - Garcia-Bunuel, Rafael
AU - Field, Michael
AU - Greenough, William B.
N1 - Funding Information:
1 Al-Awqati Qais 2 Garcia-Bunuel Rafael Field Michael Greenough William B. III Departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, and Hospital and Baltimore City Hospitals, Baltimore, Maryland 21205; and Department of Medicine, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115 1 This work was supported by The United States-Japan Cooperative Medical Science Program administered by The National Institute of Allergy and Infectious Diseases of the NIH, Department of Health, Education and Welfare Grant 5R22 AI 08209-03. 2 Present address: Renal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114. 12 1970 135 3 598 604
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1970/12
Y1 - 1970/12
N2 - Histologically normal isolated, short-circuited rabbit ileum absorbed both sodium and chloride ions. Structurally damaged mucosa did not absorb either ion. Glucose mediated short-circuit current effect was present in normal but was much reduced in abnormal tissues. These findings in tissue with altered structure were compared to tissue exposed to cholera toxin, where no net sodium absorption occurs yet net chloride movement from serosal-to-mucosal surfaces occur. In contrast to the pathological tissues the absent net sodium absorption in cholera is reversible with the addition of glucose to the mucosal medium.
AB - Histologically normal isolated, short-circuited rabbit ileum absorbed both sodium and chloride ions. Structurally damaged mucosa did not absorb either ion. Glucose mediated short-circuit current effect was present in normal but was much reduced in abnormal tissues. These findings in tissue with altered structure were compared to tissue exposed to cholera toxin, where no net sodium absorption occurs yet net chloride movement from serosal-to-mucosal surfaces occur. In contrast to the pathological tissues the absent net sodium absorption in cholera is reversible with the addition of glucose to the mucosal medium.
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U2 - 10.3181/00379727-135-35103
DO - 10.3181/00379727-135-35103
M3 - Article
C2 - 5486690
AN - SCOPUS:0014886670
SN - 0037-9727
VL - 135
SP - 598
EP - 604
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 3
ER -