The Influence of Structural Abnormality on Ion Transport in Rabbit Ileum 35103

Qais Al-Awqati, Rafael Garcia-Bunuel, Michael Field, William B. Greenough

Research output: Contribution to journalArticle

Abstract

Histologically normal isolated, short-circuited rabbit ileum absorbed both sodium and chloride ions. Structurally damaged mucosa did not absorb either ion. Glucose mediated short-circuit current effect was present in normal but was much reduced in abnormal tissues. These findings in tissue with altered structure were compared to tissue exposed to cholera toxin, where no net sodium absorption occurs yet net chloride movement from serosal-to-mucosal surfaces occur. In contrast to the pathological tissues the absent net sodium absorption in cholera is reversible with the addition of glucose to the mucosal medium.

Original languageEnglish (US)
Pages (from-to)598-604
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume135
Issue number3
DOIs
StatePublished - Dec 1970

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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