The influence of persistent pathogens on circulating levels of inflammatory markers

A cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis

Aydin Nazmi, Ana V. Diez-Roux, Nancy S. Jenny, Michael Y. Tsai, Moyses Szklo, Allison E. Aiello

Research output: Contribution to journalArticle

Abstract

Background: Systemic inflammation is linked to cardiovascular risk, but the influence of persistent pathogens, which are conventionally dichotomously categorized, on circulating levels of inflammatory markers is not clear. Antibody levels of pathogens have not been examined in relation to inflammation. Methods. Using data from a subsample of the Multi-Ethnic Study of Atherosclerosis, we examined circulating levels of interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen in relation to five common persistent pathogens: cytomegalovirus, herpes simplex virus-1, Hepatitis A virus, Helicobacter pylori and Chlamydia pneumoniae. We tested the hypothesis that the number of seropositive pathogens (based on conventional cut-off points) would not be as sensitive a marker of inflammation as immune response measured by antibody levels to pathogens. Results. High antibody response to multiple pathogens showed graded and significant associations with IL-6 (p <0.001), CRP (p = 0.04) and fibrinogen (p = 0.001), whereas seropositive pathogen burden did not. In multiple linear regression models, high antibody response to multiple pathogens maintained a positive association only with IL-6 (4.4% per pathogen exhibiting high antibody response, 95% CI 0.0-8.9). Conclusions. High antibody response to pathogens was a more consistent marker of inflammatory outcomes compared to seropositivity alone and high antibody response to multiple pathogens was a stronger marker compared to any single pathogen.

Original languageEnglish (US)
Article number706
JournalBMC Public Health
Volume10
DOIs
StatePublished - 2010

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Antibody Formation
Atherosclerosis
Cross-Sectional Studies
Interleukin-6
Inflammation
C-Reactive Protein
Fibrinogen
Linear Models
Hepatitis A virus
Chlamydophila pneumoniae
Human Herpesvirus 1
Cytomegalovirus
Helicobacter pylori
Antibodies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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The influence of persistent pathogens on circulating levels of inflammatory markers : A cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis. / Nazmi, Aydin; Diez-Roux, Ana V.; Jenny, Nancy S.; Tsai, Michael Y.; Szklo, Moyses; Aiello, Allison E.

In: BMC Public Health, Vol. 10, 706, 2010.

Research output: Contribution to journalArticle

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abstract = "Background: Systemic inflammation is linked to cardiovascular risk, but the influence of persistent pathogens, which are conventionally dichotomously categorized, on circulating levels of inflammatory markers is not clear. Antibody levels of pathogens have not been examined in relation to inflammation. Methods. Using data from a subsample of the Multi-Ethnic Study of Atherosclerosis, we examined circulating levels of interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen in relation to five common persistent pathogens: cytomegalovirus, herpes simplex virus-1, Hepatitis A virus, Helicobacter pylori and Chlamydia pneumoniae. We tested the hypothesis that the number of seropositive pathogens (based on conventional cut-off points) would not be as sensitive a marker of inflammation as immune response measured by antibody levels to pathogens. Results. High antibody response to multiple pathogens showed graded and significant associations with IL-6 (p <0.001), CRP (p = 0.04) and fibrinogen (p = 0.001), whereas seropositive pathogen burden did not. In multiple linear regression models, high antibody response to multiple pathogens maintained a positive association only with IL-6 (4.4{\%} per pathogen exhibiting high antibody response, 95{\%} CI 0.0-8.9). Conclusions. High antibody response to pathogens was a more consistent marker of inflammatory outcomes compared to seropositivity alone and high antibody response to multiple pathogens was a stronger marker compared to any single pathogen.",
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T2 - A cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis

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AU - Diez-Roux, Ana V.

AU - Jenny, Nancy S.

AU - Tsai, Michael Y.

AU - Szklo, Moyses

AU - Aiello, Allison E.

PY - 2010

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