The influence of neoadjuvant chemotherapy on breast conserving therapy and post-mastectomy radiation therapy

Richard C. Zellars

Research output: Contribution to journalArticle

Abstract

Neoadjuvant chemotherapy (NACT) has revolutionized the management of women with locally advanced breast cancer. Although this change in treatment paradigm has facilitated surgery and helped to predict outcomes in certain subsets of patients, it has also caused some confusion with respect to the role of adjuvant radiation therapy. This review discusses the benefits of NACT, the questions that arose as a result of this change in sequence, and, using the current literature, the possible answers to these questions. The reader should leave this review with a basic understanding of the issues faced by the radiation oncologist when consulting patients who have been treated with NACT.

Original languageEnglish (US)
Pages (from-to)220-224
Number of pages5
JournalCurrent Breast Cancer Reports
Volume3
Issue number4
DOIs
StatePublished - Dec 1 2011

Keywords

  • Breast cancer
  • Breast conserving therapy
  • Neoadjuvant chemotherapy
  • Post-mastectomy
  • Pre-operative chemotherapy
  • Primary chemotherapy
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology

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