The influence of mild carbon dioxide on brain functional homotopy using resting-state fMRI

Olga Marshall, Jinsoo Uh, Daniel Lurie, Hanzhang Lu, Michael P. Milham, Yulin Ge

Research output: Contribution to journalArticle

Abstract

Homotopy reflects the intrinsic functional architecture of the brain through synchronized spontaneous activity between corresponding bilateral regions, measured as voxel mirrored homotopic connectivity (VMHC). Hypercapnia is known to have clear impact on brain hemodynamics through vasodilation, but have unclear effect on neuronal activity. This study investigates the effect of hypercapnia on brain homotopy, achieved by breathing 5% carbon dioxide (CO2) gas mixture. A total of 14 healthy volunteers completed three resting state functional MRI (RS-fMRI) scans, the first and third under normocapnia and the second under hypercapnia. VMHC measures were calculated as the correlation between the BOLD signal of each voxel and its counterpart in the opposite hemisphere. Group analysis was performed between the hypercapnic and normocapnic VMHC maps. VMHC showed a diffused decrease in response to hypercapnia. Significant regional decreases in VMHC were observed in all anatomical lobes, except for the occipital lobe, in the following functional hierarchical subdivisions: the primary sensory-motor, unimodal, heteromodal, paralimbic, as well as in the following functional networks: ventral attention, somatomotor, default frontoparietal, and dorsal attention. Our observation that brain homotopy in RS-fMRI is affected by arterial CO2 levels suggests that caution should be used when comparing RS-fMRI data between healthy controls and patients with pulmonary diseases and unusual respiratory patterns such as sleep apnea or chronic obstructive pulmonary disease.

Original languageEnglish (US)
Pages (from-to)3912-3921
Number of pages10
JournalHuman Brain Mapping
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2015

Fingerprint

Hypercapnia
Carbon Dioxide
Magnetic Resonance Imaging
Brain
Occipital Lobe
Sleep Apnea Syndromes
Vasodilation
Chronic Obstructive Pulmonary Disease
Lung Diseases
Healthy Volunteers
Respiration
Gases
Hemodynamics

Keywords

  • Brain
  • Connectivity
  • Functional MRI
  • Homotopy
  • Hypercapnia
  • Resting-state

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

The influence of mild carbon dioxide on brain functional homotopy using resting-state fMRI. / Marshall, Olga; Uh, Jinsoo; Lurie, Daniel; Lu, Hanzhang; Milham, Michael P.; Ge, Yulin.

In: Human Brain Mapping, Vol. 36, No. 10, 01.10.2015, p. 3912-3921.

Research output: Contribution to journalArticle

Marshall, Olga ; Uh, Jinsoo ; Lurie, Daniel ; Lu, Hanzhang ; Milham, Michael P. ; Ge, Yulin. / The influence of mild carbon dioxide on brain functional homotopy using resting-state fMRI. In: Human Brain Mapping. 2015 ; Vol. 36, No. 10. pp. 3912-3921.
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