The influence of MicroRNAs on mitochondrial calcium

Carolina Jaquenod De Giusti, Barbara Roman, Samarjit Das

Research output: Contribution to journalReview article

Abstract

Abnormal mitochondrial calcium ([Ca2+]m) handling and energy deficiency results in cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded microRNAs (miRNA) are able to translocate in to the mitochondrial compartment, and modulate mitochondrial activities, including [Ca2+]m uptake. Apart from this subset of miRNAs, there are several miRNAs that have been reported to target genes that play a role in maintaining [Ca2+]m levels in the cytoplasm. It is imperative to validate miRNAs that alter [Ca2+]m handling, and thereby alter cellular fate. The focus of this review is to highlight the mitochondrial miRNAs (MitomiRs), and other cytosolic miRNAs that target mRNAs which play an important role in [Ca2+]m handling.

Original languageEnglish (US)
Article number1291
JournalFrontiers in Physiology
Volume9
Issue numberSEP
DOIs
StatePublished - Sep 21 2018

Keywords

  • Heart failure
  • MicroRNA
  • MiRNA
  • Mitochondria
  • Mitochondrial calcium
  • MitomiR

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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