The influence of intravenous drug use and HIV infection in the transmission of tuberculosis

Joan A. Caylà, Patricia García De Olalla, Hernando Galdós-Tangüis, Rafael Vidal, Josep Ll López-Colomés, Josep M. Gatell, Josep M. Jansà

Research output: Contribution to journalArticle

Abstract

Objective: To investigate whether smear-positive pulmonary tuberculosis (TB) patients present a different risk of TB transmission according to their HIV status, in an area where the majority of HIV-infected patients studied were intravenous drug users (IVDU). Methods: A case-control study was performed on smear-positive pulmonary TB patients diagnosed between 1990 and 1993 for whom a contact study had been performed. Patients with and without HIV infection were matched by age (± 3 years), sex and hospital of diagnosis. A micro-epidemic was defined if two or more secondary cases were detected from the same index case. Data were analysed comparing the percentage of contacts with TB in both groups. Results: Thirty-six secondary cases were detected in 436 contacts of 124 HIV-infected TB patients, whereas only 24 were identified in 624 contacts of 124 HIV-seronegative TB patients [odds ratio (OR), 2.14; 95% confidence interval (CI), 1.22-3.77; P = 0.004]. Comparing the contacts of HIV-infected patients, 34 secondary cases of TB were detected in 371 contacts of 97 IVDU, whereas only two cases were detected in 85 contacts of 27 non-IVDU (OR, 4.19; 95% CI, 1.09-15.95). HIV-seropositive index cases were observed to cause more micro-epidemics than seronegative cases (eight versus four), indicating that micro-epidemic cases were more frequent in the contacts of HIV-infected subjects (27 out of 36 versus 10 out of 24; OR, 1.41; 95% CI, 1.41-12.49; P = 0.009). All index cases in eight micro-epidemics were HIV-seropositive IVDU, whereas only four micro-epidemics were generated by HIV-seronegative subjects, none of whom were IVDU. Conclusions: Smear-positive pulmonary TB patients were more likely to transmit TB if they were HIV-infected, as evidenced by the role of IVDU in generating micro-epidemics.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalAIDS
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1996

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Keywords

  • AIDS
  • Case-control study
  • Coinfection
  • HIV
  • Infectivity
  • Intravenous drug use
  • Outbreaks
  • Risk factors
  • Transmission
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Caylà, J. A., García De Olalla, P., Galdós-Tangüis, H., Vidal, R., López-Colomés, J. L., Gatell, J. M., & Jansà, J. M. (1996). The influence of intravenous drug use and HIV infection in the transmission of tuberculosis. AIDS, 10(1), 95-100. https://doi.org/10.1097/00002030-199601000-00014