The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African Americans

Aleksandr Lazaryan, Wei Song, Elena Lobashevsky, Jianming Tang, Sadeep Shrestha, Kui Zhang, Janet M. McNicholl, Lytt I. Gardner, Craig M. Wilson, Robert S. Klein, Anne Rompalo, Kenneth Mayer, Jack Sobel, Richard A. Kaslow

Research output: Contribution to journalArticlepeer-review

Abstract

Populations of African ancestry continue to account for a disproportionate burden of the human immunodeficiency virus type 1 (HIV-1) epidemic in the United States. We investigated the effects of human leukocyte antigen (HLA) class I markers in association with virologic and immunologic control of HIV-1 infection among 338 HIV-1 subtype B-infected African Americans in 2 cohorts: Reaching for Excellence in Adolescent Care and Health (REACH) and HIV Epidemiology Research Study (HERS). One-year treatment-free interval measurements of HIV-1 RNA viral loads and CD4+ T cells were examined both separately and combined to represent 3 categories of HIV-1 disease control (76 controllers, 169 intermediates, and 93 noncontrollers). Certain previously or newly implicated HLA class I alleles (A*32, A*36, A*74, B*14, B*1510, B*3501, B*45, B*53, B*57, Cw*04, Cw*08, Cw*12, and Cw*18) were associated with 1 or more of the endpoints in univariate analyses. After multivariable adjustments for other genetic and nongenetic risk factors of HIV-1 progression, the subset of alleles more strongly or consistently associated with HIV-1 disease control included A*32, A*74, B*14, B*45, B*53, B*57, and Cw*08. Carriage of infrequent HLA-B but not HLA-A alleles was associated with more favorable disease outcomes. Certain HLA class I associations with control of HIV-1 infection cross the boundaries of race and viral subtype, whereas others appear confined within one or the other of those boundaries.

Original languageEnglish (US)
Pages (from-to)312-318
Number of pages7
JournalHuman Immunology
Volume72
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • African American
  • Allele frequency
  • HIV-1 control
  • HLA class I

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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