TY - JOUR
T1 - The influence of hormones and pharmaceutical agents on DHEA and DHEA-S concentrations
T2 - A review of clinical studies
AU - Salek, Firoozeh S.
AU - Bigos, Kristin L.
AU - Kroboth, Patricia Dowley
PY - 2002
Y1 - 2002
N2 - Low endogenous levels of dehydroepiandrosterone (DHEA) and/or its sulfoconjugated derivative DHEA-S have been associated with diseases such as lupus, cancer, and diabetes. Circulating concentrations of DHEA and DHEA-S resulting from endogenous production or hormone supplementation may also be relevant in psychiatric illness. Drugs may significantly increase or decrease circulating concentrations of these adrenal androgens by various mechanisms. Some agents, such as dexamethasone, affect the HPA axis by inhibiting ACTH and therefore decrease DHEA and DHEA-S concentrations. Central nervous system agents, including carbamazepine and phenytoin, induce the P450 enzymes that metabolize DHEA and DHEA-S and therefore decrease circulating concentrations of these hormones. Danazol alters the ratio between DHEA and DHEA-S by inhibiting sulfatase. As research moves forward to better understand the relationships of these adrenal androgens with health and disease, it is essential that studies be designed to control for the influence of administered pharmaceuticals on DHEA and DHEA-S.
AB - Low endogenous levels of dehydroepiandrosterone (DHEA) and/or its sulfoconjugated derivative DHEA-S have been associated with diseases such as lupus, cancer, and diabetes. Circulating concentrations of DHEA and DHEA-S resulting from endogenous production or hormone supplementation may also be relevant in psychiatric illness. Drugs may significantly increase or decrease circulating concentrations of these adrenal androgens by various mechanisms. Some agents, such as dexamethasone, affect the HPA axis by inhibiting ACTH and therefore decrease DHEA and DHEA-S concentrations. Central nervous system agents, including carbamazepine and phenytoin, induce the P450 enzymes that metabolize DHEA and DHEA-S and therefore decrease circulating concentrations of these hormones. Danazol alters the ratio between DHEA and DHEA-S by inhibiting sulfatase. As research moves forward to better understand the relationships of these adrenal androgens with health and disease, it is essential that studies be designed to control for the influence of administered pharmaceuticals on DHEA and DHEA-S.
UR - http://www.scopus.com/inward/record.url?scp=0036182519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036182519&partnerID=8YFLogxK
U2 - 10.1177/00912700222011274
DO - 10.1177/00912700222011274
M3 - Review article
C2 - 11865961
AN - SCOPUS:0036182519
SN - 0091-2700
VL - 42
SP - 247
EP - 266
JO - Journal of clinical pharmacology
JF - Journal of clinical pharmacology
IS - 3
ER -