Abstract
Background and Purpose: Several studies have shown diabetes mellitus (DM) is a predictor of restenosis after coronary stenting. There is little information, however, about the effect of glycemic control in diabetic patients on in-stent neointimal hyperplasia. Methods and Subjects: Serial (post-intervention and six-month follow-up) intravascular ultrasound (IVUS) was used to study 87 lesions treated with single slotted-tube stents (Multi-Link or NIR) in 80 diabetic patients. We measured cross sectional stent area (SCSA), cross-sectional lumen area (LCSA) at the axial location within the stents at the smallest follow-up area. Cross-sectional percent neointimal area (%NICSA) was calculated as below: %NICSA = (SCSA-LCSA)/SCSA × 100. HbA1C levels and fasting blood glucose (FBG) levels were measured at six-month follow-up. Good-controlled DM was defined as mean HbA1C <6.5% and mean FBG <140 mg/dl, and poor-controlled DM was defined as mean HbA1C ≳ 6.5% or mean FBG ≳ 140 mg/dl. Results: There were 42 lesions with good-controlled DM, and 45 with poor-controlled DM. No significant difference was observed between the two groups in gender, age, coronary risk factors, and SCSA at follow-up. %NICSA was greater in patients with poor-controlled DM than that in patients with good-controlled DM (34 ± 15% vs 44 ± 18%; p = 0.008). Conclusions: Glycemic control in diabetic patients plays an important roll in neointimal proliferation after stent implantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 163-167 |
| Number of pages | 5 |
| Journal | Japanese Journal of Interventional Cardiology |
| Volume | 18 |
| Issue number | 2 |
| State | Published - 2003 |
| Externally published | Yes |
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Keywords
- Diabetes mellitus
- Neointimal hyperplasia
- Stent
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging
Cite this
The influence of glycemic control in diabetic patients on neointimal hyperplasia after coronary stent implantation. / Inoue, Natsuo; Nanasato, Mamoru; Unno, Kazumasa; Shimano, Masayuki; Takefuji, Mikihito; Matsushita, Kunihiro; Yoshida, Yukihiko; Takezawa, Hiroto; Miwata, Satoru; Tsuboi, Naoya; Hirayama, Haruo.
In: Japanese Journal of Interventional Cardiology, Vol. 18, No. 2, 2003, p. 163-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The influence of glycemic control in diabetic patients on neointimal hyperplasia after coronary stent implantation
AU - Inoue, Natsuo
AU - Nanasato, Mamoru
AU - Unno, Kazumasa
AU - Shimano, Masayuki
AU - Takefuji, Mikihito
AU - Matsushita, Kunihiro
AU - Yoshida, Yukihiko
AU - Takezawa, Hiroto
AU - Miwata, Satoru
AU - Tsuboi, Naoya
AU - Hirayama, Haruo
PY - 2003
Y1 - 2003
N2 - Background and Purpose: Several studies have shown diabetes mellitus (DM) is a predictor of restenosis after coronary stenting. There is little information, however, about the effect of glycemic control in diabetic patients on in-stent neointimal hyperplasia. Methods and Subjects: Serial (post-intervention and six-month follow-up) intravascular ultrasound (IVUS) was used to study 87 lesions treated with single slotted-tube stents (Multi-Link or NIR) in 80 diabetic patients. We measured cross sectional stent area (SCSA), cross-sectional lumen area (LCSA) at the axial location within the stents at the smallest follow-up area. Cross-sectional percent neointimal area (%NICSA) was calculated as below: %NICSA = (SCSA-LCSA)/SCSA × 100. HbA1C levels and fasting blood glucose (FBG) levels were measured at six-month follow-up. Good-controlled DM was defined as mean HbA1C <6.5% and mean FBG <140 mg/dl, and poor-controlled DM was defined as mean HbA1C ≳ 6.5% or mean FBG ≳ 140 mg/dl. Results: There were 42 lesions with good-controlled DM, and 45 with poor-controlled DM. No significant difference was observed between the two groups in gender, age, coronary risk factors, and SCSA at follow-up. %NICSA was greater in patients with poor-controlled DM than that in patients with good-controlled DM (34 ± 15% vs 44 ± 18%; p = 0.008). Conclusions: Glycemic control in diabetic patients plays an important roll in neointimal proliferation after stent implantation.
AB - Background and Purpose: Several studies have shown diabetes mellitus (DM) is a predictor of restenosis after coronary stenting. There is little information, however, about the effect of glycemic control in diabetic patients on in-stent neointimal hyperplasia. Methods and Subjects: Serial (post-intervention and six-month follow-up) intravascular ultrasound (IVUS) was used to study 87 lesions treated with single slotted-tube stents (Multi-Link or NIR) in 80 diabetic patients. We measured cross sectional stent area (SCSA), cross-sectional lumen area (LCSA) at the axial location within the stents at the smallest follow-up area. Cross-sectional percent neointimal area (%NICSA) was calculated as below: %NICSA = (SCSA-LCSA)/SCSA × 100. HbA1C levels and fasting blood glucose (FBG) levels were measured at six-month follow-up. Good-controlled DM was defined as mean HbA1C <6.5% and mean FBG <140 mg/dl, and poor-controlled DM was defined as mean HbA1C ≳ 6.5% or mean FBG ≳ 140 mg/dl. Results: There were 42 lesions with good-controlled DM, and 45 with poor-controlled DM. No significant difference was observed between the two groups in gender, age, coronary risk factors, and SCSA at follow-up. %NICSA was greater in patients with poor-controlled DM than that in patients with good-controlled DM (34 ± 15% vs 44 ± 18%; p = 0.008). Conclusions: Glycemic control in diabetic patients plays an important roll in neointimal proliferation after stent implantation.
KW - Diabetes mellitus
KW - Neointimal hyperplasia
KW - Stent
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M3 - Article
AN - SCOPUS:0038334782
VL - 18
SP - 163
EP - 167
JO - Japanese Journal of Interventional Cardiology
JF - Japanese Journal of Interventional Cardiology
SN - 0914-8922
IS - 2
ER -