The influence of glycemic control in diabetic patients on neointimal hyperplasia after coronary stent implantation

Natsuo Inoue, Mamoru Nanasato, Kazumasa Unno, Masayuki Shimano, Mikihito Takefuji, Kunihiro Matsushita, Yukihiko Yoshida, Hiroto Takezawa, Satoru Miwata, Naoya Tsuboi, Haruo Hirayama

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Several studies have shown diabetes mellitus (DM) is a predictor of restenosis after coronary stenting. There is little information, however, about the effect of glycemic control in diabetic patients on in-stent neointimal hyperplasia. Methods and Subjects: Serial (post-intervention and six-month follow-up) intravascular ultrasound (IVUS) was used to study 87 lesions treated with single slotted-tube stents (Multi-Link or NIR) in 80 diabetic patients. We measured cross sectional stent area (SCSA), cross-sectional lumen area (LCSA) at the axial location within the stents at the smallest follow-up area. Cross-sectional percent neointimal area (%NICSA) was calculated as below: %NICSA = (SCSA-LCSA)/SCSA × 100. HbA1C levels and fasting blood glucose (FBG) levels were measured at six-month follow-up. Good-controlled DM was defined as mean HbA1C <6.5% and mean FBG <140 mg/dl, and poor-controlled DM was defined as mean HbA1C ≳ 6.5% or mean FBG ≳ 140 mg/dl. Results: There were 42 lesions with good-controlled DM, and 45 with poor-controlled DM. No significant difference was observed between the two groups in gender, age, coronary risk factors, and SCSA at follow-up. %NICSA was greater in patients with poor-controlled DM than that in patients with good-controlled DM (34 ± 15% vs 44 ± 18%; p = 0.008). Conclusions: Glycemic control in diabetic patients plays an important roll in neointimal proliferation after stent implantation.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalJapanese Journal of Interventional Cardiology
Volume18
Issue number2
StatePublished - 2003
Externally publishedYes

Fingerprint

Hyperplasia
Stents
Diabetes Mellitus
Blood Glucose
Fasting
Coronary Restenosis

Keywords

  • Diabetes mellitus
  • Neointimal hyperplasia
  • Stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

The influence of glycemic control in diabetic patients on neointimal hyperplasia after coronary stent implantation. / Inoue, Natsuo; Nanasato, Mamoru; Unno, Kazumasa; Shimano, Masayuki; Takefuji, Mikihito; Matsushita, Kunihiro; Yoshida, Yukihiko; Takezawa, Hiroto; Miwata, Satoru; Tsuboi, Naoya; Hirayama, Haruo.

In: Japanese Journal of Interventional Cardiology, Vol. 18, No. 2, 2003, p. 163-167.

Research output: Contribution to journalArticle

Inoue, N, Nanasato, M, Unno, K, Shimano, M, Takefuji, M, Matsushita, K, Yoshida, Y, Takezawa, H, Miwata, S, Tsuboi, N & Hirayama, H 2003, 'The influence of glycemic control in diabetic patients on neointimal hyperplasia after coronary stent implantation', Japanese Journal of Interventional Cardiology, vol. 18, no. 2, pp. 163-167.
Inoue, Natsuo ; Nanasato, Mamoru ; Unno, Kazumasa ; Shimano, Masayuki ; Takefuji, Mikihito ; Matsushita, Kunihiro ; Yoshida, Yukihiko ; Takezawa, Hiroto ; Miwata, Satoru ; Tsuboi, Naoya ; Hirayama, Haruo. / The influence of glycemic control in diabetic patients on neointimal hyperplasia after coronary stent implantation. In: Japanese Journal of Interventional Cardiology. 2003 ; Vol. 18, No. 2. pp. 163-167.
@article{c144fc47c2fb46d5a341d6323fec0163,
title = "The influence of glycemic control in diabetic patients on neointimal hyperplasia after coronary stent implantation",
abstract = "Background and Purpose: Several studies have shown diabetes mellitus (DM) is a predictor of restenosis after coronary stenting. There is little information, however, about the effect of glycemic control in diabetic patients on in-stent neointimal hyperplasia. Methods and Subjects: Serial (post-intervention and six-month follow-up) intravascular ultrasound (IVUS) was used to study 87 lesions treated with single slotted-tube stents (Multi-Link or NIR) in 80 diabetic patients. We measured cross sectional stent area (SCSA), cross-sectional lumen area (LCSA) at the axial location within the stents at the smallest follow-up area. Cross-sectional percent neointimal area ({\%}NICSA) was calculated as below: {\%}NICSA = (SCSA-LCSA)/SCSA × 100. HbA1C levels and fasting blood glucose (FBG) levels were measured at six-month follow-up. Good-controlled DM was defined as mean HbA1C <6.5{\%} and mean FBG <140 mg/dl, and poor-controlled DM was defined as mean HbA1C ≳ 6.5{\%} or mean FBG ≳ 140 mg/dl. Results: There were 42 lesions with good-controlled DM, and 45 with poor-controlled DM. No significant difference was observed between the two groups in gender, age, coronary risk factors, and SCSA at follow-up. {\%}NICSA was greater in patients with poor-controlled DM than that in patients with good-controlled DM (34 ± 15{\%} vs 44 ± 18{\%}; p = 0.008). Conclusions: Glycemic control in diabetic patients plays an important roll in neointimal proliferation after stent implantation.",
keywords = "Diabetes mellitus, Neointimal hyperplasia, Stent",
author = "Natsuo Inoue and Mamoru Nanasato and Kazumasa Unno and Masayuki Shimano and Mikihito Takefuji and Kunihiro Matsushita and Yukihiko Yoshida and Hiroto Takezawa and Satoru Miwata and Naoya Tsuboi and Haruo Hirayama",
year = "2003",
language = "English (US)",
volume = "18",
pages = "163--167",
journal = "Japanese Journal of Interventional Cardiology",
issn = "0914-8922",
publisher = "Japanese Society of Interventional Cardiology",
number = "2",

}

TY - JOUR

T1 - The influence of glycemic control in diabetic patients on neointimal hyperplasia after coronary stent implantation

AU - Inoue, Natsuo

AU - Nanasato, Mamoru

AU - Unno, Kazumasa

AU - Shimano, Masayuki

AU - Takefuji, Mikihito

AU - Matsushita, Kunihiro

AU - Yoshida, Yukihiko

AU - Takezawa, Hiroto

AU - Miwata, Satoru

AU - Tsuboi, Naoya

AU - Hirayama, Haruo

PY - 2003

Y1 - 2003

N2 - Background and Purpose: Several studies have shown diabetes mellitus (DM) is a predictor of restenosis after coronary stenting. There is little information, however, about the effect of glycemic control in diabetic patients on in-stent neointimal hyperplasia. Methods and Subjects: Serial (post-intervention and six-month follow-up) intravascular ultrasound (IVUS) was used to study 87 lesions treated with single slotted-tube stents (Multi-Link or NIR) in 80 diabetic patients. We measured cross sectional stent area (SCSA), cross-sectional lumen area (LCSA) at the axial location within the stents at the smallest follow-up area. Cross-sectional percent neointimal area (%NICSA) was calculated as below: %NICSA = (SCSA-LCSA)/SCSA × 100. HbA1C levels and fasting blood glucose (FBG) levels were measured at six-month follow-up. Good-controlled DM was defined as mean HbA1C <6.5% and mean FBG <140 mg/dl, and poor-controlled DM was defined as mean HbA1C ≳ 6.5% or mean FBG ≳ 140 mg/dl. Results: There were 42 lesions with good-controlled DM, and 45 with poor-controlled DM. No significant difference was observed between the two groups in gender, age, coronary risk factors, and SCSA at follow-up. %NICSA was greater in patients with poor-controlled DM than that in patients with good-controlled DM (34 ± 15% vs 44 ± 18%; p = 0.008). Conclusions: Glycemic control in diabetic patients plays an important roll in neointimal proliferation after stent implantation.

AB - Background and Purpose: Several studies have shown diabetes mellitus (DM) is a predictor of restenosis after coronary stenting. There is little information, however, about the effect of glycemic control in diabetic patients on in-stent neointimal hyperplasia. Methods and Subjects: Serial (post-intervention and six-month follow-up) intravascular ultrasound (IVUS) was used to study 87 lesions treated with single slotted-tube stents (Multi-Link or NIR) in 80 diabetic patients. We measured cross sectional stent area (SCSA), cross-sectional lumen area (LCSA) at the axial location within the stents at the smallest follow-up area. Cross-sectional percent neointimal area (%NICSA) was calculated as below: %NICSA = (SCSA-LCSA)/SCSA × 100. HbA1C levels and fasting blood glucose (FBG) levels were measured at six-month follow-up. Good-controlled DM was defined as mean HbA1C <6.5% and mean FBG <140 mg/dl, and poor-controlled DM was defined as mean HbA1C ≳ 6.5% or mean FBG ≳ 140 mg/dl. Results: There were 42 lesions with good-controlled DM, and 45 with poor-controlled DM. No significant difference was observed between the two groups in gender, age, coronary risk factors, and SCSA at follow-up. %NICSA was greater in patients with poor-controlled DM than that in patients with good-controlled DM (34 ± 15% vs 44 ± 18%; p = 0.008). Conclusions: Glycemic control in diabetic patients plays an important roll in neointimal proliferation after stent implantation.

KW - Diabetes mellitus

KW - Neointimal hyperplasia

KW - Stent

UR - http://www.scopus.com/inward/record.url?scp=0038334782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038334782&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0038334782

VL - 18

SP - 163

EP - 167

JO - Japanese Journal of Interventional Cardiology

JF - Japanese Journal of Interventional Cardiology

SN - 0914-8922

IS - 2

ER -