The influence of diagnostic criteria on the mortality findings in the university group diabetic programme study of diabetic therapy

Research output: Contribution to journalArticle

Abstract

The University Group Diabetic Programme (UGDP) clinical trial of diabetic therapy demonstrated a higher mortality from cardiovascular disease amongst patients treated with oral hypoglycaemic agents. However, these results may have been biased by imbalances between treatment groups in the proportion of patients who were unequivocally diabetic. In order to eliminate this potential bias and to increase the specificity of the diabetic diagnosis, the UGDP mortality findings have been reassessed, using multiple diagnostic criteria as a basis for case selection. The use of multiple diagnostic criteria increases the mortality differences between the patients treated with oral hypoglycaemic agents and those treated by placebo and diet. This reinforces the original findings of the UGDP study.

Original languageEnglish (US)
Pages (from-to)594-596
Number of pages3
JournalMedical Journal of Australia
Volume1
Issue number12
StatePublished - 1973
Externally publishedYes

Fingerprint

Hypoglycemic Agents
Mortality
Cardiovascular Diseases
Therapeutics
Placebos
Clinical Trials
Diet

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{4d6d23ef9a44466ebc02f469d2e467f5,
title = "The influence of diagnostic criteria on the mortality findings in the university group diabetic programme study of diabetic therapy",
abstract = "The University Group Diabetic Programme (UGDP) clinical trial of diabetic therapy demonstrated a higher mortality from cardiovascular disease amongst patients treated with oral hypoglycaemic agents. However, these results may have been biased by imbalances between treatment groups in the proportion of patients who were unequivocally diabetic. In order to eliminate this potential bias and to increase the specificity of the diabetic diagnosis, the UGDP mortality findings have been reassessed, using multiple diagnostic criteria as a basis for case selection. The use of multiple diagnostic criteria increases the mortality differences between the patients treated with oral hypoglycaemic agents and those treated by placebo and diet. This reinforces the original findings of the UGDP study.",
author = "Gray, {Ronald H}",
year = "1973",
language = "English (US)",
volume = "1",
pages = "594--596",
journal = "Medical Journal of Australia",
issn = "0025-729X",
publisher = "Australasian Medical Publishing Co. Ltd",
number = "12",

}

TY - JOUR

T1 - The influence of diagnostic criteria on the mortality findings in the university group diabetic programme study of diabetic therapy

AU - Gray, Ronald H

PY - 1973

Y1 - 1973

N2 - The University Group Diabetic Programme (UGDP) clinical trial of diabetic therapy demonstrated a higher mortality from cardiovascular disease amongst patients treated with oral hypoglycaemic agents. However, these results may have been biased by imbalances between treatment groups in the proportion of patients who were unequivocally diabetic. In order to eliminate this potential bias and to increase the specificity of the diabetic diagnosis, the UGDP mortality findings have been reassessed, using multiple diagnostic criteria as a basis for case selection. The use of multiple diagnostic criteria increases the mortality differences between the patients treated with oral hypoglycaemic agents and those treated by placebo and diet. This reinforces the original findings of the UGDP study.

AB - The University Group Diabetic Programme (UGDP) clinical trial of diabetic therapy demonstrated a higher mortality from cardiovascular disease amongst patients treated with oral hypoglycaemic agents. However, these results may have been biased by imbalances between treatment groups in the proportion of patients who were unequivocally diabetic. In order to eliminate this potential bias and to increase the specificity of the diabetic diagnosis, the UGDP mortality findings have been reassessed, using multiple diagnostic criteria as a basis for case selection. The use of multiple diagnostic criteria increases the mortality differences between the patients treated with oral hypoglycaemic agents and those treated by placebo and diet. This reinforces the original findings of the UGDP study.

UR - http://www.scopus.com/inward/record.url?scp=0015838747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015838747&partnerID=8YFLogxK

M3 - Article

C2 - 4573383

AN - SCOPUS:0015838747

VL - 1

SP - 594

EP - 596

JO - Medical Journal of Australia

JF - Medical Journal of Australia

SN - 0025-729X

IS - 12

ER -