Abstract
It is unknown if any particular anticonvulsants modify the likelihood of seizure reduction when used in combination with the ketogenic diet (KD). A retrospective study was performed of 217 consecutive children who started the KD from 2000-2007. Patients included did not have any changes to their anticonvulsant dose. Efficacy data at 3 months on the KD were analyzed with respect to the six most frequently used anticonvulsants in this cohort. A total of 115 patients were included. Children receiving phenobarbital in combination with the KD were significantly less likely to have a >50% seizure reduction (p = 0.003). Conversely, those receiving zonisamide in combination with the KD at onset were more likely to have a >50% reduction (p = 0.04). These results provide practical information to clinicians who are treating children receiving both the KD and anticonvulsants.
Original language | English (US) |
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Pages (from-to) | 1999-2001 |
Number of pages | 3 |
Journal | Epilepsia |
Volume | 50 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2009 |
Keywords
- Anticonvulsants
- Children
- Diet
- Epilepsy
- Ketogenic
ASJC Scopus subject areas
- Neurology
- Clinical Neurology