The influence of castration on pharmacologically induced penile erection in the cat

Trinity Bivalacqua, Mahadevan Rajasekaran, Hunter C. Champion, Run Wang, Suresh C. Sikka, Philip J. Kadowitz, Wayne J G Hellstrom

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to investigate the in vivo effects of intracavernosal injections of adrenomedullin (ADM), calcitonin gene-related peptide (CGRP), nociceptin, vasoactive intestinal polypeptide (VIP), sodium nitroprusside (SNP), and prostaglandin E, (PGE(t)) on penile erection in castrated and intact (control) anesthesized cats. Erectile responses to ADM, CGRP, nociceptin, VIP, SNP, and PGE, were compared with responses to a standard triple-drug combination (1.65 mg of papaverine, 25 μg of phentolamine, and 0.5 μg of PGE(t)) in both castrated and control cats in control animals. ADM, CGRP, nociceptin, VIP, SNP, and PGE(t) induced penile erections similar to those elicited by the triple-drug combination. However, in castrated animals, there was a significant decrease in erectile response; the response to intracavernosal injection of the standard triple-drug combination in castrated cats was 28% of that of the control group of animals. Serum testosterone levels demonstrated a significant (P <0.0001) positive correlation (r = 0.52) with intracavernosal pressure in response to the standard combination. A marked reduction in serum testosterone levels was observed in castrated cats when measured by radioimmunoassay (0.34 ± 0.1 ng/dl in castrated cats, compared with 31.15 ± 6 ng/dl in control cats). These data suggest that the presence of testosterone is a necessary prerequisite to sustain a pharmacologically induced penile erection in the cat.

Original languageEnglish (US)
Pages (from-to)551-557
Number of pages7
JournalJournal of Andrology
Volume19
Issue number5
StatePublished - Sep 1998
Externally publishedYes

Fingerprint

Penile Erection
Castration
Cats
Prostaglandins E
Adrenomedullin
Calcitonin Gene-Related Peptide
Vasoactive Intestinal Peptide
Nitroprusside
Drug Combinations
Testosterone
Papaverine
Injections
Phentolamine
Serum
Radioimmunoassay
Pressure
Control Groups

Keywords

  • cAMP
  • cGMP
  • Testosterone
  • Vasoactive agents

ASJC Scopus subject areas

  • Endocrinology

Cite this

Bivalacqua, T., Rajasekaran, M., Champion, H. C., Wang, R., Sikka, S. C., Kadowitz, P. J., & Hellstrom, W. J. G. (1998). The influence of castration on pharmacologically induced penile erection in the cat. Journal of Andrology, 19(5), 551-557.

The influence of castration on pharmacologically induced penile erection in the cat. / Bivalacqua, Trinity; Rajasekaran, Mahadevan; Champion, Hunter C.; Wang, Run; Sikka, Suresh C.; Kadowitz, Philip J.; Hellstrom, Wayne J G.

In: Journal of Andrology, Vol. 19, No. 5, 09.1998, p. 551-557.

Research output: Contribution to journalArticle

Bivalacqua, T, Rajasekaran, M, Champion, HC, Wang, R, Sikka, SC, Kadowitz, PJ & Hellstrom, WJG 1998, 'The influence of castration on pharmacologically induced penile erection in the cat', Journal of Andrology, vol. 19, no. 5, pp. 551-557.
Bivalacqua T, Rajasekaran M, Champion HC, Wang R, Sikka SC, Kadowitz PJ et al. The influence of castration on pharmacologically induced penile erection in the cat. Journal of Andrology. 1998 Sep;19(5):551-557.
Bivalacqua, Trinity ; Rajasekaran, Mahadevan ; Champion, Hunter C. ; Wang, Run ; Sikka, Suresh C. ; Kadowitz, Philip J. ; Hellstrom, Wayne J G. / The influence of castration on pharmacologically induced penile erection in the cat. In: Journal of Andrology. 1998 ; Vol. 19, No. 5. pp. 551-557.
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