### Abstract

This study investigated the influence of biological and technical factors on variations of global and regional cerebral metabolic rate of glucose (CMR_{glc}) measured with 2-[^{18}F]fluoro-2-deoxy-D-glucose ([^{18}F]FDG). Twelve male volunteers (22-40 years) were investigated on three or four occasions for a total of 42 studies. We calculated the variance/covariance of the following parameters: CMR_{glc}, six parameters of the blood clearance of [^{18}F]FDG, hour of injection, peak time of blood radioactivity, and six components of the operational equation (nonradioactive blood glucose concentration, brain radioactivity, two integrals, numerator, and denominator). There was correlation among these six components, except for nonradioactive blood glucose. However, the correlation between the CMR_{glc} and the individual components of the operational equation was poor. The inter- and intrapersonal CMR_{glc} coefficients of variations were 13.8 and 7.1%, respectively. In contrast, coefficients of variations of the numerator and denominator of the operational equation were 34.6 and 32.6%, respectively, and were always in the same direction. No correlation was found between CMR_{glc} and the technical factors in the numerator and denominator of the operational equation. Factor analysis disclosed that a single factor was responsible for 70% of the variance. This factor included caudate, putamen, thalamus, frontal cortex, temporal cortex, and cingulate gyrus. These structures are involved with multiple complex functions, from autonomic motor control to behavior and emotions. The intrinsic metabolic variability of these structures, along with the basal metabolic processes that are continuously going on in the brain, may be the best explanation for the variance encountered in our investigation.

Original language | English (US) |
---|---|

Pages (from-to) | 281-290 |

Number of pages | 10 |

Journal | Journal of Cerebral Blood Flow and Metabolism |

Volume | 12 |

Issue number | 2 |

State | Published - 1992 |

### Fingerprint

### Keywords

- Brain metabolism
- Deoxyglucose variance
- Factor analysis
- Positron emission tomography

### ASJC Scopus subject areas

- Endocrinology
- Neuroscience(all)
- Endocrinology, Diabetes and Metabolism

### Cite this

*Journal of Cerebral Blood Flow and Metabolism*,

*12*(2), 281-290.

**The influence of biological and technical factors on the variability of global and regional brain metabolism of 2-[18F]fluoro-2-deoxy-D-glucose.** / Camargo, Edwaldo E.; Szabo, Zsolt; Links, Jonathan M; Sostre, Samuel; Dannals, Robert F; Wagner, Henry N.

Research output: Contribution to journal › Article

*Journal of Cerebral Blood Flow and Metabolism*, vol. 12, no. 2, pp. 281-290.

}

TY - JOUR

T1 - The influence of biological and technical factors on the variability of global and regional brain metabolism of 2-[18F]fluoro-2-deoxy-D-glucose

AU - Camargo, Edwaldo E.

AU - Szabo, Zsolt

AU - Links, Jonathan M

AU - Sostre, Samuel

AU - Dannals, Robert F

AU - Wagner, Henry N.

PY - 1992

Y1 - 1992

N2 - This study investigated the influence of biological and technical factors on variations of global and regional cerebral metabolic rate of glucose (CMRglc) measured with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG). Twelve male volunteers (22-40 years) were investigated on three or four occasions for a total of 42 studies. We calculated the variance/covariance of the following parameters: CMRglc, six parameters of the blood clearance of [18F]FDG, hour of injection, peak time of blood radioactivity, and six components of the operational equation (nonradioactive blood glucose concentration, brain radioactivity, two integrals, numerator, and denominator). There was correlation among these six components, except for nonradioactive blood glucose. However, the correlation between the CMRglc and the individual components of the operational equation was poor. The inter- and intrapersonal CMRglc coefficients of variations were 13.8 and 7.1%, respectively. In contrast, coefficients of variations of the numerator and denominator of the operational equation were 34.6 and 32.6%, respectively, and were always in the same direction. No correlation was found between CMRglc and the technical factors in the numerator and denominator of the operational equation. Factor analysis disclosed that a single factor was responsible for 70% of the variance. This factor included caudate, putamen, thalamus, frontal cortex, temporal cortex, and cingulate gyrus. These structures are involved with multiple complex functions, from autonomic motor control to behavior and emotions. The intrinsic metabolic variability of these structures, along with the basal metabolic processes that are continuously going on in the brain, may be the best explanation for the variance encountered in our investigation.

AB - This study investigated the influence of biological and technical factors on variations of global and regional cerebral metabolic rate of glucose (CMRglc) measured with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG). Twelve male volunteers (22-40 years) were investigated on three or four occasions for a total of 42 studies. We calculated the variance/covariance of the following parameters: CMRglc, six parameters of the blood clearance of [18F]FDG, hour of injection, peak time of blood radioactivity, and six components of the operational equation (nonradioactive blood glucose concentration, brain radioactivity, two integrals, numerator, and denominator). There was correlation among these six components, except for nonradioactive blood glucose. However, the correlation between the CMRglc and the individual components of the operational equation was poor. The inter- and intrapersonal CMRglc coefficients of variations were 13.8 and 7.1%, respectively. In contrast, coefficients of variations of the numerator and denominator of the operational equation were 34.6 and 32.6%, respectively, and were always in the same direction. No correlation was found between CMRglc and the technical factors in the numerator and denominator of the operational equation. Factor analysis disclosed that a single factor was responsible for 70% of the variance. This factor included caudate, putamen, thalamus, frontal cortex, temporal cortex, and cingulate gyrus. These structures are involved with multiple complex functions, from autonomic motor control to behavior and emotions. The intrinsic metabolic variability of these structures, along with the basal metabolic processes that are continuously going on in the brain, may be the best explanation for the variance encountered in our investigation.

KW - Brain metabolism

KW - Deoxyglucose variance

KW - Factor analysis

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0026517599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026517599&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 281

EP - 290

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 2

ER -