The influence of anticoagulant therapy on the incidence of thromboembolism, hemorrhage and cardiac rupture in acute myocardial infarction. Correlation of clinical and autopsy data in 100 cases

Nicholas E. Capeci, Robert L. Levy

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. Analysis was made of the clinical records and autopsy protocols of 100 patients who died with acute myocardial infarction. Fifty were given adequate anticoagulant therapy; fifty did not receive anticoagulants. 2. 2. Postmortem examinations revealed many errors in clinical diagnosis, both with respect to the presence of a recent cardiac infarct and of thromboembolic complications. At autopsy, such complications were found with equal frequency in treated and untreated groups. The incidence was not modified by the presence of congestive heart failure. 3. 3. Major hemorrhage was observed in six of the treated cases; in three, death was attributed to this cause. 4. 4. In 239 patients adequately treated and 557 untreated, assembled by combining this and three reported series, myocardial rutpure was found at autopsy three times as often in the treated as in the untreated. 5. 5. Because numerous sources of bias are unavoidable when the records of a hospital population are used as the basis of a postmortem study, the results are not suitable for meaningful statistical analysis. However, only by a comparison with autopsy findings can the accuracy of clinical diagnoses be checked. The present study has demonstrated trends which seem definite.

Original languageEnglish (US)
Pages (from-to)76-80
Number of pages5
JournalAmerican Journal of Medicine
Volume26
Issue number1
StatePublished - Jan 1959
Externally publishedYes

ASJC Scopus subject areas

  • Nursing(all)
  • Medicine(all)

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