The inflammatory response in transgastric surgery: Gastric content leak leads to localized inflammatory response and higher adhesive disease

Sonia L. Ramamoorthy, Jeffrey K. Lee, Linda Luo, Yoav Mintz, John Cullen, David W. Easter, Michelle K. Savu, Alana Chock, John Carethers, Santiago Horgan, Mark A. Talamini

Research output: Contribution to journalArticle

Abstract

Background Risk of gastric spillage during transgastric surgery is a potential complication of NOTES procedures. The aim of this study was to determine risk outcomes from gastric spillage in a rat survival model by measuring local and systemic inflammatory markers, adhesive disease, and morbidity. Methods We performed a minilaparotomy with needle aspiration of 2 ml of gastric contents mixed with 2 ml of sterile saline (study group, SG) or 4 ml of sterile saline (control group, CG) injected into the peritoneal cavity of 60 male rats. Inflammatory markers (TNFα, IL-6, and IL- 10) were analyzed at 1, 3, 6, and 24 h postoperatively by obtaining plasma levels and peritoneal washings. At necropsy, the peritoneal cavity was examined grossly for adhesions. Results Adhesions were seen more frequently in the SG versus the CG (100% vs. 33.3%, p

Original languageEnglish (US)
Pages (from-to)531-535
Number of pages5
JournalSurgical Endoscopy and Other Interventional Techniques
Volume24
Issue number3
DOIs
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

Gastrointestinal Contents
Peritoneal Cavity
Adhesives
Stomach
Control Groups
Interleukin-10
Laparotomy
Needles
Interleukin-6
Morbidity

Keywords

  • Natural orifice surgery
  • NOTES
  • Transgastric surgery

ASJC Scopus subject areas

  • Surgery

Cite this

The inflammatory response in transgastric surgery : Gastric content leak leads to localized inflammatory response and higher adhesive disease. / Ramamoorthy, Sonia L.; Lee, Jeffrey K.; Luo, Linda; Mintz, Yoav; Cullen, John; Easter, David W.; Savu, Michelle K.; Chock, Alana; Carethers, John; Horgan, Santiago; Talamini, Mark A.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 24, No. 3, 03.2010, p. 531-535.

Research output: Contribution to journalArticle

Ramamoorthy, SL, Lee, JK, Luo, L, Mintz, Y, Cullen, J, Easter, DW, Savu, MK, Chock, A, Carethers, J, Horgan, S & Talamini, MA 2010, 'The inflammatory response in transgastric surgery: Gastric content leak leads to localized inflammatory response and higher adhesive disease', Surgical Endoscopy and Other Interventional Techniques, vol. 24, no. 3, pp. 531-535. https://doi.org/10.1007/s00464-009-0636-7
Ramamoorthy, Sonia L. ; Lee, Jeffrey K. ; Luo, Linda ; Mintz, Yoav ; Cullen, John ; Easter, David W. ; Savu, Michelle K. ; Chock, Alana ; Carethers, John ; Horgan, Santiago ; Talamini, Mark A. / The inflammatory response in transgastric surgery : Gastric content leak leads to localized inflammatory response and higher adhesive disease. In: Surgical Endoscopy and Other Interventional Techniques. 2010 ; Vol. 24, No. 3. pp. 531-535.
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